Matches in SemOpenAlex for { <https://semopenalex.org/work/W2568702871> ?p ?o ?g. }
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- W2568702871 startingPage "8" @default.
- W2568702871 abstract "Current anti-angiogenic therapies in malignant and ocular diseases target growth factor signaling in order to attenuate excessive vascular growth. Although initial responses are promising, overall therapeutic success is limited due to insufficient efficiency, tumor refractoriness and resistance. Emerging evidence suggests that diverse growth factor signaling pathways in endothelial cells (ECs) converge onto cellular metabolism, creating an attractive target for novel alternative anti-angiogenic therapies. Recent studies show that ECs rely on glycolysis for ATP and biomass synthesis, necessary for proliferation and migration, key processes of angiogenesis. In addition, fatty acid β-oxidation (FAO) is essential for de novo nucleotide synthesis during EC proliferation. Initial proof-of-evidence has been given that administration of pharmacological inhibitors of those metabolic pathways can be used to inhibit pathological angiogenesis in vivo. Deciphering the role of other metabolic pathways and exploring the therapeutic potential of blocking these pathways await further investigation." @default.
- W2568702871 created "2017-01-13" @default.
- W2568702871 creator A5000233630 @default.
- W2568702871 creator A5008058267 @default.
- W2568702871 creator A5047152113 @default.
- W2568702871 creator A5056236473 @default.
- W2568702871 date "2017-03-01" @default.
- W2568702871 modified "2023-09-25" @default.
- W2568702871 title "Targeting endothelial metabolism for anti-angiogenesis therapy: A pharmacological perspective" @default.
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