Matches in SemOpenAlex for { <https://semopenalex.org/work/W2568753744> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W2568753744 abstract "Recently much attention has been focused in the research of curcumin, a secondary metabolite isolated from Curcuma longa L. and from other species of Curcuma. Current investigation of curcumin is fastly increasing due to its biological activities (anti-inflammatory, [1] antioxidant, anti-HIV, [2] including cytotoxic effects on several cancer line cells [3, 4] and upon cystic fibrosis [5]). A benzothiazol derivative of curcumin was obtained by systematic structural modification of curcumin (Scheme). We have described previously the synthesis of new heterocyclic derivatives of curcumin including the compound 4 [6]. The benzothiazol 4 was prepared by the reaction of 3 and 2-aminobenzenethiol. During the ring formation a part of the molecule of curcumin suffered fragmentation. The structure of 4 was assessed by spectroscopic methods (IR, 1D and 2D NMR, mass spectrometry), also the crystal structure was analyzed by X-ray crystallography. In our preliminary biological studies, compound 4 has shown important cytotoxic effect toward a nasopharyngeal carcinoma cell line KB (ED50 =3.38µg/mL) as well as modification of the percentage of cells on cell cycle phases of the monocytic human cell line TPH1. Acknowledgements: CONACYT of Mexico (37821-N and 40959-Q); DGAPA of UNAM (IN232202). References: 1. Ali, M., et al. (1995), Ind. J. Chem. 34B: 884. 2. Artico, M., et al. (1998), J. Med. Chem., 41: 3948. 3. Huang, M.T., et al. (1992), ACS Symposium Series 507: 338. 4. Ishida, J. et al. (2002), Biorg. Med. Chem. 10: 3481. 5. Egan, M. F. et al. (2004), Science, 304: 600. 6. M. Concepcion Lozada, et al., (2004), Heterocycles 65: 49." @default.
- W2568753744 created "2017-01-13" @default.
- W2568753744 creator A5020309444 @default.
- W2568753744 creator A5034297540 @default.
- W2568753744 creator A5042710700 @default.
- W2568753744 creator A5043617091 @default.
- W2568753744 creator A5057281667 @default.
- W2568753744 creator A5067057314 @default.
- W2568753744 date "2006-08-24" @default.
- W2568753744 modified "2023-10-18" @default.
- W2568753744 title "Synthesis and biological activity of a new benzothiazol derivative of curcumin" @default.
- W2568753744 doi "https://doi.org/10.1055/s-2006-949891" @default.
- W2568753744 hasPublicationYear "2006" @default.
- W2568753744 type Work @default.
- W2568753744 sameAs 2568753744 @default.
- W2568753744 citedByCount "1" @default.
- W2568753744 crossrefType "journal-article" @default.
- W2568753744 hasAuthorship W2568753744A5020309444 @default.
- W2568753744 hasAuthorship W2568753744A5034297540 @default.
- W2568753744 hasAuthorship W2568753744A5042710700 @default.
- W2568753744 hasAuthorship W2568753744A5043617091 @default.
- W2568753744 hasAuthorship W2568753744A5057281667 @default.
- W2568753744 hasAuthorship W2568753744A5067057314 @default.
- W2568753744 hasConcept C106159729 @default.
- W2568753744 hasConcept C111771559 @default.
- W2568753744 hasConcept C162324750 @default.
- W2568753744 hasConcept C185592680 @default.
- W2568753744 hasConcept C2777477808 @default.
- W2568753744 hasConcept C2778250585 @default.
- W2568753744 hasConcept C55493867 @default.
- W2568753744 hasConcept C71240020 @default.
- W2568753744 hasConceptScore W2568753744C106159729 @default.
- W2568753744 hasConceptScore W2568753744C111771559 @default.
- W2568753744 hasConceptScore W2568753744C162324750 @default.
- W2568753744 hasConceptScore W2568753744C185592680 @default.
- W2568753744 hasConceptScore W2568753744C2777477808 @default.
- W2568753744 hasConceptScore W2568753744C2778250585 @default.
- W2568753744 hasConceptScore W2568753744C55493867 @default.
- W2568753744 hasConceptScore W2568753744C71240020 @default.
- W2568753744 hasIssue "11" @default.
- W2568753744 hasLocation W25687537441 @default.
- W2568753744 hasOpenAccess W2568753744 @default.
- W2568753744 hasPrimaryLocation W25687537441 @default.
- W2568753744 hasRelatedWork W1983655658 @default.
- W2568753744 hasRelatedWork W2068203377 @default.
- W2568753744 hasRelatedWork W2365534900 @default.
- W2568753744 hasRelatedWork W2748952813 @default.
- W2568753744 hasRelatedWork W2899084033 @default.
- W2568753744 hasRelatedWork W2949632328 @default.
- W2568753744 hasRelatedWork W2952578443 @default.
- W2568753744 hasRelatedWork W2953014029 @default.
- W2568753744 hasRelatedWork W3005124540 @default.
- W2568753744 hasRelatedWork W3009705489 @default.
- W2568753744 hasVolume "72" @default.
- W2568753744 isParatext "false" @default.
- W2568753744 isRetracted "false" @default.
- W2568753744 magId "2568753744" @default.
- W2568753744 workType "article" @default.