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• W2568754411 abstract "Sphingolipids are structural components in the plasma membranes of eukaryotic cells. Their metabolism produces bioactive signaling molecules that modulate fundamental cellular processes. The segregation of sphingolipids into distinct membrane domains is likely essential for cellular function. This review presents the early studies of sphingolipid distribution in the plasma membranes of mammalian cells that shaped the most popular current model of plasma membrane organization. The results of traditional imaging studies of sphingolipid distribution in stimulated and resting cells are described. These data are compared with recent results obtained with advanced imaging techniques, including super-resolution fluorescence detection and high-resolution secondary ion mass spectrometry (SIMS). Emphasis is placed on the new insight into the sphingolipid organization within the plasma membrane that has resulted from the direct imaging of stable isotope-labeled lipids in actual cell membranes with high-resolution SIMS. Super-resolution fluorescence techniques have recently revealed the biophysical behaviors of sphingolipids and the unhindered diffusion of cholesterol analogs in the membranes of living cells are ultimately in contrast to the prevailing hypothetical model of plasma membrane organization. High-resolution SIMS studies also conflicted with the prevailing hypothesis, showing sphingolipids are concentrated in micrometer-scale membrane domains, but cholesterol is evenly distributed within the plasma membrane. Reductions in cellular cholesterol decreased the number of sphingolipid domains in the plasma membrane, whereas disruption of the cytoskeleton eliminated them. In addition, hemagglutinin, a transmembrane protein that is thought to be a putative raft marker, did not cluster within sphingolipid-enriched regions in the plasma membrane. Thus, sphingolipid distribution in the plasma membrane is dependent on the cytoskeleton, but not on favorable interactions with cholesterol or hemagglutinin. The alternate views of plasma membrane organization suggested by these findings are discussed." @default.
• W2568754411 created "2017-01-13" @default.
• W2568754411 creator A5058689865 @default.
• W2568754411 date "2017-01-10" @default.
• W2568754411 modified "2023-10-17" @default.
• W2568754411 title "Sphingolipid Organization in the Plasma Membrane and the Mechanisms That Influence It" @default.
• W2568754411 cites W100202703 @default.
• W2568754411 cites W1484375250 @default.
• W2568754411 cites W1505007136 @default.
• W2568754411 cites W1520176015 @default.
• W2568754411 cites W1536767595 @default.
• W2568754411 cites W1564861448 @default.
• W2568754411 cites W1566441785 @default.
• W2568754411 cites W1581414531 @default.
• W2568754411 cites W1603021076 @default.
• W2568754411 cites W1607687470 @default.
• W2568754411 cites W1671853446 @default.
• W2568754411 cites W1678039705 @default.
• W2568754411 cites W1748288754 @default.
• W2568754411 cites W1885689715 @default.
• W2568754411 cites W1898709484 @default.
• W2568754411 cites W1936864590 @default.
• W2568754411 cites W1965287866 @default.
• W2568754411 cites W1966452335 @default.
• W2568754411 cites W1967950972 @default.
• W2568754411 cites W1969258330 @default.
• W2568754411 cites W1969577836 @default.
• W2568754411 cites W1970271391 @default.
• W2568754411 cites W1970417068 @default.
• W2568754411 cites W1970503159 @default.
• W2568754411 cites W1970561430 @default.
• W2568754411 cites W1974928798 @default.
• W2568754411 cites W1976608157 @default.
• W2568754411 cites W1977004640 @default.
• W2568754411 cites W1978821123 @default.
• W2568754411 cites W1979166300 @default.
• W2568754411 cites W1980088140 @default.
• W2568754411 cites W1981916955 @default.
• W2568754411 cites W1983755242 @default.
• W2568754411 cites W1985357723 @default.
• W2568754411 cites W1986269705 @default.
• W2568754411 cites W1986962215 @default.
• W2568754411 cites W1987717533 @default.
• W2568754411 cites W1988530230 @default.
• W2568754411 cites W1988712957 @default.
• W2568754411 cites W1990912620 @default.
• W2568754411 cites W1992692912 @default.
• W2568754411 cites W1993093223 @default.
• W2568754411 cites W1999288258 @default.
• W2568754411 cites W2001980248 @default.
• W2568754411 cites W2004296371 @default.
• W2568754411 cites W2007179492 @default.
• W2568754411 cites W2007524790 @default.
• W2568754411 cites W2007604755 @default.
• W2568754411 cites W2008640020 @default.
• W2568754411 cites W2009808097 @default.
• W2568754411 cites W2011790546 @default.
• W2568754411 cites W2012523344 @default.
• W2568754411 cites W2013295182 @default.
• W2568754411 cites W2014310021 @default.
• W2568754411 cites W2014503023 @default.
• W2568754411 cites W2017729786 @default.
• W2568754411 cites W2018072142 @default.
• W2568754411 cites W2019027747 @default.
• W2568754411 cites W2019288241 @default.
• W2568754411 cites W2019502270 @default.
• W2568754411 cites W2019979753 @default.
• W2568754411 cites W2020204057 @default.
• W2568754411 cites W2020682711 @default.
• W2568754411 cites W2021882008 @default.
• W2568754411 cites W2022248964 @default.
• W2568754411 cites W2022497999 @default.
• W2568754411 cites W2022757461 @default.
• W2568754411 cites W2024692900 @default.
• W2568754411 cites W2028973883 @default.
• W2568754411 cites W2032451465 @default.
• W2568754411 cites W2036009804 @default.
• W2568754411 cites W2036187254 @default.
• W2568754411 cites W2036428426 @default.
• W2568754411 cites W2037735248 @default.
• W2568754411 cites W2037916829 @default.
• W2568754411 cites W2040855268 @default.
• W2568754411 cites W2041391144 @default.
• W2568754411 cites W2041423967 @default.
• W2568754411 cites W2042045827 @default.
• W2568754411 cites W2043312574 @default.
• W2568754411 cites W2045122620 @default.
• W2568754411 cites W2047899060 @default.
• W2568754411 cites W2048887344 @default.
• W2568754411 cites W2049190436 @default.
• W2568754411 cites W2049914201 @default.
• W2568754411 cites W2050719403 @default.
• W2568754411 cites W2052017158 @default.
• W2568754411 cites W2052201373 @default.
• W2568754411 cites W2053204073 @default.
• W2568754411 cites W2053550995 @default.
• W2568754411 cites W2053697213 @default.
• W2568754411 cites W2053858732 @default.
• W2568754411 cites W2054826743 @default.
• W2568754411 cites W2055794329 @default.

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