FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2568757791> ?p ?o ?g. }

• W2568757791 endingPage "2841" @default.
• W2568757791 startingPage "2830" @default.
• W2568757791 abstract "The serine/threonine kinase Unc-51-like kinase-1 (Ulk1) is thought to be essential for induction of autophagy, an intracellular bulk degradation process that is activated by various stresses. Although several proteins have been suggested as Ulk1 substrates during autophagic process, it still remains largely unknown about Ulk1's physiological substrates. Here, by performing in vitro and in vivo phosphorylation assay, we report that the co-chaperone cell division cycle protein 37 (Cdc37) is a Ulk1 substrate. Ulk1-mediated phosphorylation of Ser-339 in Cdc37 compromised the recruitment of client kinases to a complex comprising Cdc37 and heat shock protein 90 (Hsp90) but only modestly affected Cdc37 binding to Hsp90. Because the recruitment of protein kinase clients to the Hsp90 complex is essential for their stability and functions, Ser-339 phosphorylation of Cdc37 disrupts its ability as a co-chaperone to coordinate Hsp90. Hsp90 inhibitors are cancer chemotherapeutic agents by inducing depletion of clients, many of which are oncogenes. Upon treatment with an Hsp90 inhibitor in cancer cells, Ulk1 promoted the degradation of Hsp90-Cdc37 client kinases, resulting in increased cellular sensitivity to Hsp90 inhibitors. Thus, our study provides evidence for an anti-proliferative role of Ulk1 in response to Hsp90 inhibition in cancer cells." @default.
• W2568757791 created "2017-01-13" @default.
• W2568757791 creator A5009318195 @default.
• W2568757791 creator A5016919565 @default.
• W2568757791 creator A5028295358 @default.
• W2568757791 creator A5042533031 @default.
• W2568757791 creator A5042947574 @default.
• W2568757791 creator A5050395333 @default.
• W2568757791 creator A5054364968 @default.
• W2568757791 creator A5062451164 @default.
• W2568757791 creator A5068176076 @default.
• W2568757791 creator A5080633583 @default.
• W2568757791 creator A5089773457 @default.
• W2568757791 date "2017-02-01" @default.
• W2568757791 modified "2023-10-17" @default.
• W2568757791 title "Serine/Threonine Kinase Unc-51-like Kinase-1 (Ulk1) Phosphorylates the Co-chaperone Cell Division Cycle Protein 37 (Cdc37) and Thereby Disrupts the Stability of Cdc37 Client Proteins" @default.
• W2568757791 cites W1486418814 @default.
• W2568757791 cites W1504365021 @default.
• W2568757791 cites W1534985842 @default.
• W2568757791 cites W1546731875 @default.
• W2568757791 cites W1918384196 @default.
• W2568757791 cites W1968432606 @default.
• W2568757791 cites W1970637701 @default.
• W2568757791 cites W1972184193 @default.
• W2568757791 cites W1975733191 @default.
• W2568757791 cites W1976980728 @default.
• W2568757791 cites W1991582269 @default.
• W2568757791 cites W1993902022 @default.
• W2568757791 cites W1999211990 @default.
• W2568757791 cites W2016771009 @default.
• W2568757791 cites W2034212405 @default.
• W2568757791 cites W2036901614 @default.
• W2568757791 cites W2038007890 @default.
• W2568757791 cites W2055304293 @default.
• W2568757791 cites W2055339736 @default.
• W2568757791 cites W2063650770 @default.
• W2568757791 cites W2065592028 @default.
• W2568757791 cites W2066844134 @default.
• W2568757791 cites W2075401349 @default.
• W2568757791 cites W2076570319 @default.
• W2568757791 cites W2085483616 @default.
• W2568757791 cites W2087510837 @default.
• W2568757791 cites W2087536904 @default.
• W2568757791 cites W2092931855 @default.
• W2568757791 cites W2095485251 @default.
• W2568757791 cites W2096308078 @default.
• W2568757791 cites W2103659405 @default.
• W2568757791 cites W2109167860 @default.
• W2568757791 cites W2113038168 @default.
• W2568757791 cites W2113432343 @default.
• W2568757791 cites W2116458487 @default.
• W2568757791 cites W2120176605 @default.
• W2568757791 cites W2133090498 @default.
• W2568757791 cites W2147358450 @default.
• W2568757791 cites W2150168624 @default.
• W2568757791 cites W2156144699 @default.
• W2568757791 cites W2157096314 @default.
• W2568757791 cites W2161803468 @default.
• W2568757791 cites W2164998112 @default.
• W2568757791 cites W2166999544 @default.
• W2568757791 cites W2257365899 @default.
• W2568757791 cites W2339584249 @default.
• W2568757791 cites W2346316685 @default.
• W2568757791 cites W2398577671 @default.
• W2568757791 cites W2480458405 @default.
• W2568757791 doi "https://doi.org/10.1074/jbc.m116.762443" @default.
• W2568757791 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5314178" @default.
• W2568757791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28073914" @default.
• W2568757791 hasPublicationYear "2017" @default.
• W2568757791 type Work @default.
• W2568757791 sameAs 2568757791 @default.
• W2568757791 citedByCount "15" @default.
• W2568757791 countsByYear W25687577912017 @default.
• W2568757791 countsByYear W25687577912018 @default.
• W2568757791 countsByYear W25687577912019 @default.
• W2568757791 countsByYear W25687577912020 @default.
• W2568757791 countsByYear W25687577912021 @default.
• W2568757791 countsByYear W25687577912022 @default.
• W2568757791 countsByYear W25687577912023 @default.
• W2568757791 crossrefType "journal-article" @default.
• W2568757791 hasAuthorship W2568757791A5009318195 @default.
• W2568757791 hasAuthorship W2568757791A5016919565 @default.
• W2568757791 hasAuthorship W2568757791A5028295358 @default.
• W2568757791 hasAuthorship W2568757791A5042533031 @default.
• W2568757791 hasAuthorship W2568757791A5042947574 @default.
• W2568757791 hasAuthorship W2568757791A5050395333 @default.
• W2568757791 hasAuthorship W2568757791A5054364968 @default.
• W2568757791 hasAuthorship W2568757791A5062451164 @default.
• W2568757791 hasAuthorship W2568757791A5068176076 @default.
• W2568757791 hasAuthorship W2568757791A5080633583 @default.
• W2568757791 hasAuthorship W2568757791A5089773457 @default.
• W2568757791 hasBestOaLocation W25687577911 @default.
• W2568757791 hasConcept C104615370 @default.
• W2568757791 hasConcept C11960822 @default.
• W2568757791 hasConcept C124160383 @default.
• W2568757791 hasConcept C155985219 @default.
• W2568757791 hasConcept C171896709 @default.
• W2568757791 hasConcept C184235292 @default.

• next