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- W2568823086 abstract "Background: The need for second-line antitubercular medication has been on the increase due to the emergence of multidrug-resistant strain tuberculosis (MDR-TB) in our environment.Aim: This study was to assess the effect of second-line antitubercular medication on hearing in patients with MDR-TB.Patients and Methods: This is a prospective study of all the patients admitted to the MDR-TB center of the University of Port Harcourt Teaching Hospital between January and May 2013. All patients had pure tone audiometry done before and 3 months after commencement of second-line antitubercular medications. The second-line regimen used includes kanamycin, levofloxacin, cycloserine, pyrazinamide, and pyridoxine.Results: The study had a total of 28 patients. There were 14 males and 14 females. The age range was between 18 and 68 years. Different degrees of high-frequency sensorineural hearing loss (SNHL) were seen in 14 patients after 3 months' therapy. There were 13 bilateral and 1 unilateral hearing impairment, 2 patients had profound SNHL. However, a good number had involvement of the speech frequencies.Conclusion: Second-line antitubercular medication appears to have a tremendous effect on hearing. This raises a public health issue since there is a growing increase in MDR-TB in our environment." @default.
- W2568823086 created "2017-01-13" @default.
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- W2568823086 date "2016-01-01" @default.
- W2568823086 modified "2023-09-27" @default.
- W2568823086 title "Pure tone audiometric findings in patients on second-line treatment for multidrug-resistant tuberculosis" @default.
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- W2568823086 doi "https://doi.org/10.4103/0795-3038.197748" @default.
- W2568823086 hasPublicationYear "2016" @default.
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