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- W2568839938 abstract "Abstract Abstract 4652 Objective This study was purposed to analyze the mutations of JAK1 in bone marrow cells from adult patients with newly-diagnosed T cell acute lymphoblastic leukemia (T-ALL). Methods The entire coding sequence of JAK1 in bone marrow mononuclear cells (MNCs) from 40 adult T cell ALL patients were screened by polymerase chain reaction (PCR) and direct sequencing, then the clinical features of JAK1 mutation positive patients were analyzed. Results JAK1 mutations were identified in 5%(2/40) patients, one is point mutation, the other is insertion mutation, resulting in changes in amino acid sequences, and the two types of mutations are different from those mutations found before. Conclusion The JAK1 mutations were found in about 5% newly-diagnosed T cell acute lymphoblastic leukemia, which was lower than those report abroad. Disclosures: No relevant conflicts of interest to declare." @default.
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- W2568839938 date "2010-11-19" @default.
- W2568839938 modified "2023-09-30" @default.
- W2568839938 title "Identification of JAK1 Mutation In 40 Cases of Adult Acute T Lymphoblastic Leukemia" @default.
- W2568839938 doi "https://doi.org/10.1182/blood.v116.21.4652.4652" @default.
- W2568839938 hasPublicationYear "2010" @default.
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