FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2568851657> ?p ?o ?g. }

• W2568851657 endingPage "183" @default.
• W2568851657 startingPage "172" @default.
• W2568851657 abstract "Protein tyrosine phosphatase 1B (PTP1B) regulates leptin signaling in hypothalamic neurons via the JAK2-STAT3 pathway. PTP1B has also been implicated in the regulation of inflammation in the periphery. However, the role of PTP1B in hypothalamic inflammation, which is induced by a high-fat diet (HFD), remains to be elucidated. Here, we showed that STAT3 phosphorylation (p-STAT3) was increased in microglia in the hypothalamic arcuate nucleus of PTP1B knock-out mice (KO) on a HFD, accompanied by decreased Tnf and increased Il10 mRNA expression in the hypothalamus compared to wild-type mice (WT). In hypothalamic organotypic cultures, incubation with TNFα led to increased p-STAT3, accompanied by decreased Tnf and increased Il10 mRNA expression, in KO compared to WT. Incubation with p-STAT3 inhibitors or microglial depletion eliminated the differences in inflammation between genotypes. These data indicate an important role of JAK2-STAT3 signaling negatively regulated by PTP1B in microglia, which attenuates hypothalamic inflammation under HFD conditions." @default.
• W2568851657 created "2017-01-13" @default.
• W2568851657 creator A5000524509 @default.
• W2568851657 creator A5001267309 @default.
• W2568851657 creator A5023680031 @default.
• W2568851657 creator A5025867348 @default.
• W2568851657 creator A5036730014 @default.
• W2568851657 creator A5058997945 @default.
• W2568851657 creator A5063848123 @default.
• W2568851657 creator A5064633359 @default.
• W2568851657 creator A5066807335 @default.
• W2568851657 creator A5067006897 @default.
• W2568851657 creator A5068981167 @default.
• W2568851657 creator A5073798277 @default.
• W2568851657 creator A5088084624 @default.
• W2568851657 date "2017-02-01" @default.
• W2568851657 modified "2023-10-17" @default.
• W2568851657 title "Deficiency of PTP1B Attenuates Hypothalamic Inflammation via Activation of the JAK2-STAT3 Pathway in Microglia" @default.
• W2568851657 cites W1512072195 @default.
• W2568851657 cites W1563577784 @default.
• W2568851657 cites W1591670144 @default.
• W2568851657 cites W1614648489 @default.
• W2568851657 cites W1619712336 @default.
• W2568851657 cites W1900570432 @default.
• W2568851657 cites W1933914530 @default.
• W2568851657 cites W1963696719 @default.
• W2568851657 cites W1964562779 @default.
• W2568851657 cites W1970223395 @default.
• W2568851657 cites W1974838371 @default.
• W2568851657 cites W1995300425 @default.
• W2568851657 cites W1999829139 @default.
• W2568851657 cites W2005428340 @default.
• W2568851657 cites W2020778360 @default.
• W2568851657 cites W2025131475 @default.
• W2568851657 cites W2032260589 @default.
• W2568851657 cites W2032977105 @default.
• W2568851657 cites W2037604062 @default.
• W2568851657 cites W2045522606 @default.
• W2568851657 cites W2052302932 @default.
• W2568851657 cites W2054915373 @default.
• W2568851657 cites W2059647625 @default.
• W2568851657 cites W2062548726 @default.
• W2568851657 cites W2066083217 @default.
• W2568851657 cites W2068545173 @default.
• W2568851657 cites W2070582535 @default.
• W2568851657 cites W2070855360 @default.
• W2568851657 cites W2074303577 @default.
• W2568851657 cites W2076499590 @default.
• W2568851657 cites W2077033935 @default.
• W2568851657 cites W2078409165 @default.
• W2568851657 cites W2078730804 @default.
• W2568851657 cites W2079395662 @default.
• W2568851657 cites W2087482176 @default.
• W2568851657 cites W2091988898 @default.
• W2568851657 cites W2094702051 @default.
• W2568851657 cites W2101798805 @default.
• W2568851657 cites W2109659841 @default.
• W2568851657 cites W2115681043 @default.
• W2568851657 cites W2116507947 @default.
• W2568851657 cites W2118743996 @default.
• W2568851657 cites W2120790798 @default.
• W2568851657 cites W2121039744 @default.
• W2568851657 cites W2122832744 @default.
• W2568851657 cites W2137601030 @default.
• W2568851657 cites W2142851934 @default.
• W2568851657 cites W2142924698 @default.
• W2568851657 cites W2154696002 @default.
• W2568851657 cites W2159566868 @default.
• W2568851657 cites W2162035041 @default.
• W2568851657 cites W2285624671 @default.
• W2568851657 cites W2293196234 @default.
• W2568851657 cites W2338321186 @default.
• W2568851657 doi "https://doi.org/10.1016/j.ebiom.2017.01.007" @default.
• W2568851657 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5474442" @default.
• W2568851657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28094236" @default.
• W2568851657 hasPublicationYear "2017" @default.
• W2568851657 type Work @default.
• W2568851657 sameAs 2568851657 @default.
• W2568851657 citedByCount "48" @default.
• W2568851657 countsByYear W25688516572017 @default.
• W2568851657 countsByYear W25688516572018 @default.
• W2568851657 countsByYear W25688516572019 @default.
• W2568851657 countsByYear W25688516572020 @default.
• W2568851657 countsByYear W25688516572021 @default.
• W2568851657 countsByYear W25688516572022 @default.
• W2568851657 countsByYear W25688516572023 @default.
• W2568851657 crossrefType "journal-article" @default.
• W2568851657 hasAuthorship W2568851657A5000524509 @default.
• W2568851657 hasAuthorship W2568851657A5001267309 @default.
• W2568851657 hasAuthorship W2568851657A5023680031 @default.
• W2568851657 hasAuthorship W2568851657A5025867348 @default.
• W2568851657 hasAuthorship W2568851657A5036730014 @default.
• W2568851657 hasAuthorship W2568851657A5058997945 @default.
• W2568851657 hasAuthorship W2568851657A5063848123 @default.
• W2568851657 hasAuthorship W2568851657A5064633359 @default.
• W2568851657 hasAuthorship W2568851657A5066807335 @default.
• W2568851657 hasAuthorship W2568851657A5067006897 @default.
• W2568851657 hasAuthorship W2568851657A5068981167 @default.

• next