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• W2568878869 abstract "Abstract Dietary long-chain n -3 PUFA ( n -3 LCPUFA) in infancy may have long-term effects on lifestyle disease risk. The present follow-up study investigated whether maternal fish oil (FO) supplementation during lactation affected growth and blood pressure in adolescents and whether the effects differed between boys and girls. Mother–infant pairs ( n 103) completed a randomised controlled trial with FO (1·5 g/d n -3 LCPUFA) or olive oil (OO) supplements during the first 4 months of lactation; forty-seven mother–infant pairs with high fish intake were followed-up for 4 months as the reference group. We also followed-up 100 children with assessment of growth, blood pressure, diet by FFQ and physical activity by 7-d accelerometry at 13·5 ( sd 0·4) years of age. Dried whole-blood fatty acid composition was analysed in a subgroup ( n 49). At 13 years of age, whole-blood n -3 LCPUFA, diet, physical activity and body composition did not differ between the three groups. The children from the FO group were 3·4 (95 % CI 0·2, 6·6) cm shorter ( P =0·035) than those from the OO group, and tended to have less advanced puberty ( P =0·068), which explained the difference in height. There was a sex-specific effect on diastolic blood pressure ( P sex×group =0·020), which was driven by a 3·9 (95 % CI 0·2, 7·5) mmHg higher diastolic blood pressure in the FO compared with the OO group among boys only ( P =0·041). Our results indicate that early n -3 LCPUFA intake may reduce height in early adolescence due to a delay in pubertal maturation and increase blood pressure specifically in boys, thereby tending to counteract existing sex differences." @default.
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• W2568878869 date "2016-12-28" @default.
• W2568878869 modified "2023-10-15" @default.
• W2568878869 title "Maternal fish oil supplementation during lactation is associated with reduced height at 13 years of age and higher blood pressure in boys only" @default.
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• W2568878869 doi "https://doi.org/10.1017/s0007114516004293" @default.
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