FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2569040056> ?p ?o ?g. }

• W2569040056 endingPage "786" @default.
• W2569040056 startingPage "780" @default.
• W2569040056 abstract "Prolyl oligopeptidase (POP) is a serine endopeptidase widely distributed in vivo with high activity in the liver. However, its biological functions in the liver have remained largely elusive. A previous study by our group has shown that POP produced N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) and thereby exerted an anti-fibrogenic effect on hepatic stellate cells (HSCs) in vitro. It was therefore hypothesized that POP may affect the activation state of HSCs and has an important role in liver fibrosis. The HSC-T6 immortalized rat liver stellate cell line was treated with the POP inhibitor S17092 or transfected with recombinant lentivirus to overexpress POP. Cell proliferation and apoptosis were determined using a Cell Counting Kit-8 and flow cytometry, respectively. The activation status of HSCs was determined by examination of the expression of α-smooth muscle actin (α-SMA), collagen I, monocyte chemoattractant protein-1 (MCP-1), transforming growth factor (TGF)-β-Smad signaling and peroxisome proliferator activated receptor-γ (PPAR-γ). Inhibition by S17092 decreased, whereas lentiviral expression increased the activity of POP and cell proliferation, while neither of the treatments affected cell apoptosis. Of note, S17092 significantly increased, whereas POP overexpression decreased the expression of α-SMA and MCP-1 without affecting the expression of collagen I and TGF-β1. Furthermore, S17092 caused a reduction, whereas POP overexpression caused an upregulation of Smad7 protein and PPAR-γ, but not phosphorylated-Smad2/3 expression. In conclusion, POP attenuated the activation of HSCs through inhibition of TGF-β signaling and induction of PPAR-γ, which may have therapeutic potential in liver fibrosis." @default.
• W2569040056 created "2017-01-13" @default.
• W2569040056 creator A5036904111 @default.
• W2569040056 creator A5037677450 @default.
• W2569040056 creator A5043188795 @default.
• W2569040056 creator A5046201209 @default.
• W2569040056 creator A5058431987 @default.
• W2569040056 creator A5066234327 @default.
• W2569040056 creator A5079116621 @default.
• W2569040056 date "2017-01-05" @default.
• W2569040056 modified "2023-09-30" @default.
• W2569040056 title "Prolyl oligopeptidase attenuates hepatic stellate cell activation through induction of Smad7 and PPAR-γ" @default.
• W2569040056 cites W144005866 @default.
• W2569040056 cites W1528825153 @default.
• W2569040056 cites W1553444759 @default.
• W2569040056 cites W1891883676 @default.
• W2569040056 cites W1906235443 @default.
• W2569040056 cites W1970779494 @default.
• W2569040056 cites W1970784741 @default.
• W2569040056 cites W1971767541 @default.
• W2569040056 cites W1983421708 @default.
• W2569040056 cites W1989984498 @default.
• W2569040056 cites W1995378781 @default.
• W2569040056 cites W1998968327 @default.
• W2569040056 cites W1999374106 @default.
• W2569040056 cites W2001183293 @default.
• W2569040056 cites W2002733746 @default.
• W2569040056 cites W2009888336 @default.
• W2569040056 cites W2014559623 @default.
• W2569040056 cites W2017096262 @default.
• W2569040056 cites W2017961355 @default.
• W2569040056 cites W2026777107 @default.
• W2569040056 cites W2029295535 @default.
• W2569040056 cites W2038430559 @default.
• W2569040056 cites W2039426167 @default.
• W2569040056 cites W2047119289 @default.
• W2569040056 cites W2054036316 @default.
• W2569040056 cites W2057095258 @default.
• W2569040056 cites W2057442268 @default.
• W2569040056 cites W2057723682 @default.
• W2569040056 cites W2058170527 @default.
• W2569040056 cites W2060827550 @default.
• W2569040056 cites W2067990598 @default.
• W2569040056 cites W2070174430 @default.
• W2569040056 cites W2072234373 @default.
• W2569040056 cites W2075636841 @default.
• W2569040056 cites W2076869555 @default.
• W2569040056 cites W2079080809 @default.
• W2569040056 cites W2080987817 @default.
• W2569040056 cites W2083686908 @default.
• W2569040056 cites W2084722601 @default.
• W2569040056 cites W2087110345 @default.
• W2569040056 cites W2090905598 @default.
• W2569040056 cites W2097765297 @default.
• W2569040056 cites W2101958831 @default.
• W2569040056 cites W2107277218 @default.
• W2569040056 cites W2111288662 @default.
• W2569040056 cites W2126957535 @default.
• W2569040056 cites W2131089867 @default.
• W2569040056 cites W2133673279 @default.
• W2569040056 cites W2136005024 @default.
• W2569040056 cites W2136380843 @default.
• W2569040056 cites W2147131319 @default.
• W2569040056 cites W2164462329 @default.
• W2569040056 cites W2188009983 @default.
• W2569040056 cites W2192080449 @default.
• W2569040056 cites W4211030739 @default.
• W2569040056 cites W4211047743 @default.
• W2569040056 cites W4236485099 @default.
• W2569040056 doi "https://doi.org/10.3892/etm.2017.4033" @default.
• W2569040056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5348651" @default.
• W2569040056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28352366" @default.
• W2569040056 hasPublicationYear "2017" @default.
• W2569040056 type Work @default.
• W2569040056 sameAs 2569040056 @default.
• W2569040056 citedByCount "11" @default.
• W2569040056 countsByYear W25690400562017 @default.
• W2569040056 countsByYear W25690400562018 @default.
• W2569040056 countsByYear W25690400562019 @default.
• W2569040056 countsByYear W25690400562020 @default.
• W2569040056 countsByYear W25690400562021 @default.
• W2569040056 countsByYear W25690400562022 @default.
• W2569040056 countsByYear W25690400562023 @default.
• W2569040056 crossrefType "journal-article" @default.
• W2569040056 hasAuthorship W2569040056A5036904111 @default.
• W2569040056 hasAuthorship W2569040056A5037677450 @default.
• W2569040056 hasAuthorship W2569040056A5043188795 @default.
• W2569040056 hasAuthorship W2569040056A5046201209 @default.
• W2569040056 hasAuthorship W2569040056A5058431987 @default.
• W2569040056 hasAuthorship W2569040056A5066234327 @default.
• W2569040056 hasAuthorship W2569040056A5079116621 @default.
• W2569040056 hasBestOaLocation W25690400561 @default.
• W2569040056 hasConcept C104317684 @default.
• W2569040056 hasConcept C127561419 @default.
• W2569040056 hasConcept C134018914 @default.
• W2569040056 hasConcept C153911025 @default.
• W2569040056 hasConcept C170493617 @default.
• W2569040056 hasConcept C176891718 @default.

• next