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• W2569069462 abstract "In the past decade, large-scale movements of DNA double strand breaks (DSBs) have repeatedly been identified following DNA damage. These mobility events include clustering, anchoring or peripheral movement at subnuclear structures. Recent work suggests roles for motion in homology search and in break sequestration to preclude deleterious outcomes. Yet, the precise functions of these movements still remain relatively obscure, and the same holds true for the determinants. Here we review recent advances in this exciting area of research, and highlight that a recurrent characteristic of mobile DSBs may lie in their inability to undergo rapid repair. A major future challenge remains to understand how DSB mobility impacts on genome integrity." @default.
• W2569069462 created "2017-01-13" @default.
• W2569069462 creator A5002034757 @default.
• W2569069462 creator A5074543116 @default.
• W2569069462 date "2017-06-01" @default.
• W2569069462 modified "2023-10-13" @default.
• W2569069462 title "Organizing DNA repair in the nucleus: DSBs hit the road" @default.
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• W2569069462 doi "https://doi.org/10.1016/j.ceb.2016.12.003" @default.
• W2569069462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28068556" @default.
• W2569069462 hasPublicationYear "2017" @default.
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