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- W2569087788 endingPage "322" @default.
- W2569087788 startingPage "308" @default.
- W2569087788 abstract "Small molecule drugs and probes are important tools in drug discovery, pharmacology, and cell biology. This is of course also true for epigenetic inhibitors. Important examples for the use of established epigenetic inhibitors are the study of the mechanistic role of a certain target in a cellular setting or the modulation of a certain phenotype in an approach that aims toward therapeutic application. Alternatively, cellular testing may aim at the validation of a new epigenetic inhibitor in drug discovery approaches. Cellular and eventually animal models provide powerful tools for these different approaches but certain caveats have to be recognized and taken into account. This involves both the selectivity of the pharmacological tool as well as the specificity and the robustness of the cellular system. In this article, we present an overview of different methods that are used to profile and screen for epigenetic agents and comment on their limitations. We describe not only diverse successful case studies of screening approaches using different assay formats, but also some problematic cases, critically discussing selected applications of these systems." @default.
- W2569087788 created "2017-01-13" @default.
- W2569087788 creator A5000189394 @default.
- W2569087788 creator A5016266091 @default.
- W2569087788 creator A5028571661 @default.
- W2569087788 creator A5060437642 @default.
- W2569087788 creator A5062326051 @default.
- W2569087788 date "2017-01-10" @default.
- W2569087788 modified "2023-09-25" @default.
- W2569087788 title "Cellular analysis of the action of epigenetic drugs and probes" @default.
- W2569087788 cites W1480171318 @default.
- W2569087788 cites W1481633630 @default.
- W2569087788 cites W1509082650 @default.
- W2569087788 cites W1516646538 @default.
- W2569087788 cites W153421366 @default.
- W2569087788 cites W1534367952 @default.
- W2569087788 cites W1559920963 @default.
- W2569087788 cites W1564505145 @default.
- W2569087788 cites W1577520625 @default.
- W2569087788 cites W1587031596 @default.
- W2569087788 cites W1595815978 @default.
- W2569087788 cites W1599677668 @default.
- W2569087788 cites W1603797292 @default.
- W2569087788 cites W1920958927 @default.
- W2569087788 cites W1963553964 @default.
- W2569087788 cites W1964943230 @default.
- W2569087788 cites W1966429292 @default.
- W2569087788 cites W1967764418 @default.
- W2569087788 cites W1968076212 @default.
- W2569087788 cites W1972304747 @default.
- W2569087788 cites W1979674523 @default.
- W2569087788 cites W1991641420 @default.
- W2569087788 cites W1992213480 @default.
- W2569087788 cites W1993251792 @default.
- W2569087788 cites W1993434836 @default.
- W2569087788 cites W1999608828 @default.
- W2569087788 cites W2000078385 @default.
- W2569087788 cites W2000106654 @default.
- W2569087788 cites W2001527591 @default.
- W2569087788 cites W2003681344 @default.
- W2569087788 cites W2004729837 @default.
- W2569087788 cites W2010407535 @default.
- W2569087788 cites W2010429928 @default.
- W2569087788 cites W2016033175 @default.
- W2569087788 cites W2017511302 @default.
- W2569087788 cites W2022285476 @default.
- W2569087788 cites W2028927305 @default.
- W2569087788 cites W2032696829 @default.
- W2569087788 cites W2035813163 @default.
- W2569087788 cites W2039623374 @default.
- W2569087788 cites W2041265190 @default.
- W2569087788 cites W2041535798 @default.
- W2569087788 cites W2041997366 @default.
- W2569087788 cites W2044000724 @default.
- W2569087788 cites W2054621094 @default.
- W2569087788 cites W2060424322 @default.
- W2569087788 cites W2063375109 @default.
- W2569087788 cites W2063644741 @default.
- W2569087788 cites W2064971912 @default.
- W2569087788 cites W2066264051 @default.
- W2569087788 cites W2068200486 @default.
- W2569087788 cites W2071958789 @default.
- W2569087788 cites W2076333986 @default.
- W2569087788 cites W2082139701 @default.
- W2569087788 cites W2082467262 @default.
- W2569087788 cites W2082633436 @default.
- W2569087788 cites W2084897539 @default.
- W2569087788 cites W2086342381 @default.
- W2569087788 cites W2086469988 @default.
- W2569087788 cites W2087254150 @default.
- W2569087788 cites W2090601659 @default.
- W2569087788 cites W2090757807 @default.
- W2569087788 cites W2090954400 @default.
- W2569087788 cites W2098249941 @default.
- W2569087788 cites W2098356010 @default.
- W2569087788 cites W2098641832 @default.
- W2569087788 cites W2100972878 @default.
- W2569087788 cites W2101127235 @default.
- W2569087788 cites W2104209180 @default.
- W2569087788 cites W2111044125 @default.
- W2569087788 cites W2116381732 @default.
- W2569087788 cites W2122344714 @default.
- W2569087788 cites W2132834292 @default.
- W2569087788 cites W2132880072 @default.
- W2569087788 cites W2133209813 @default.
- W2569087788 cites W2136406044 @default.
- W2569087788 cites W2144929276 @default.
- W2569087788 cites W2145275398 @default.
- W2569087788 cites W2150416393 @default.
- W2569087788 cites W2151743649 @default.
- W2569087788 cites W2155073819 @default.
- W2569087788 cites W2159907048 @default.
- W2569087788 cites W2165459745 @default.
- W2569087788 cites W2165906907 @default.
- W2569087788 cites W2170618531 @default.
- W2569087788 cites W2281955860 @default.
- W2569087788 cites W2283746267 @default.
- W2569087788 cites W2288695834 @default.