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- W2569148237 abstract "Abstract The main aim of this work was to synthesise a new (E)-3-(4-or3-Aminophenylimino) quinoxaline-2(3 H )-one oxime Schiff base derivatives and evaluate the anti-leptospiral activity against Leptospira icterohaemorrhagiae . The mentioned derivatives were prepared by performing microwave-assisted condensation reactions of (E)-3-(4-or3-Aminophenyl imino)quinoxaline-2(3 H )-one and aromatic aldehydes. The structures of these interesting compounds were characterised by FT-IR, 1 H NMR and mass spectroscopy. Furthermore, these compounds were screened for spirocidal activity against Leptospira icterohaemorrhagiae by using in vitro and in vivo method. The anti-leptospiral activity result reveals that most of the compounds were exhibiting considerable activity against Leptospira icterohaemorrhagiae . Compound 6c demonstrated remarkable activity at low concentration against the Leptospira icterohaemorrhagiae as compared to the standard drugs." @default.
- W2569148237 created "2017-01-13" @default.
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- W2569148237 date "2017-03-01" @default.
- W2569148237 modified "2023-09-23" @default.
- W2569148237 title "Microwave-assisted synthesis, structural activity relationship and biological activity of some new quinoxaline Schiff base derivatives as highly potent spirochete bactericidal agents" @default.
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- W2569148237 doi "https://doi.org/10.1016/j.bjbas.2016.12.007" @default.
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