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- W2569159701 endingPage "L391" @default.
- W2569159701 startingPage "L371" @default.
- W2569159701 abstract "Various pathophysiological conditions such as surfactant dysfunction, mechanical ventilation, inflammation, pathogen products, environmental exposures, and gastric acid aspiration stress lung cells, and the compromise of plasma membranes occurs as a result. The mechanisms necessary for cells to repair plasma membrane defects have been extensively investigated in the last two decades, and some of these key repair mechanisms are also shown to occur following lung cell injury. Because it was theorized that lung wounding and repair are involved in the pathogenesis of acute respiratory distress syndrome (ARDS) and idiopathic pulmonary fibrosis (IPF), in this review, we summarized the experimental evidence of lung cell injury in these two devastating syndromes and discuss relevant genetic, physical, and biological injury mechanisms, as well as mechanisms used by lung cells for cell survival and membrane repair. Finally, we discuss relevant signaling pathways that may be activated by chronic or repeated lung cell injury as an extension of our cell injury and repair focus in this review. We hope that a holistic view of injurious stimuli relevant for ARDS and IPF could lead to updated experimental models. In addition, parallel discussion of membrane repair mechanisms in lung cells and injury-activated signaling pathways would encourage research to bridge gaps in current knowledge. Indeed, deep understanding of lung cell wounding and repair, and discovery of relevant repair moieties for lung cells, should inspire the development of new therapies that are likely preventive and broadly effective for targeting injurious pulmonary diseases." @default.
- W2569159701 created "2017-01-13" @default.
- W2569159701 creator A5013779064 @default.
- W2569159701 creator A5044499311 @default.
- W2569159701 creator A5060830196 @default.
- W2569159701 creator A5076906385 @default.
- W2569159701 date "2017-03-01" @default.
- W2569159701 modified "2023-10-01" @default.
- W2569159701 title "Plasma membrane wounding and repair in pulmonary diseases" @default.
- W2569159701 cites W1531984034 @default.
- W2569159701 cites W1540058980 @default.
- W2569159701 cites W1565069188 @default.
- W2569159701 cites W156899709 @default.
- W2569159701 cites W1569431722 @default.
- W2569159701 cites W1574278217 @default.
- W2569159701 cites W1583292237 @default.
- W2569159701 cites W1605708617 @default.
- W2569159701 cites W1606402950 @default.
- W2569159701 cites W1687290736 @default.
- W2569159701 cites W1754557093 @default.
- W2569159701 cites W1768355854 @default.
- W2569159701 cites W1778071738 @default.
- W2569159701 cites W1803784511 @default.
- W2569159701 cites W1813348667 @default.
- W2569159701 cites W1821732051 @default.
- W2569159701 cites W1826487857 @default.
- W2569159701 cites W1852229048 @default.
- W2569159701 cites W1923205821 @default.
- W2569159701 cites W1943537065 @default.
- W2569159701 cites W1964182229 @default.
- W2569159701 cites W1968295892 @default.
- W2569159701 cites W1968477506 @default.
- W2569159701 cites W1968754725 @default.
- W2569159701 cites W1969613854 @default.
- W2569159701 cites W1970351187 @default.
- W2569159701 cites W1970791305 @default.
- W2569159701 cites W1972494520 @default.
- W2569159701 cites W1973098243 @default.
- W2569159701 cites W1973641896 @default.
- W2569159701 cites W1974174322 @default.
- W2569159701 cites W1974879451 @default.
- W2569159701 cites W1975115574 @default.
- W2569159701 cites W1975915958 @default.
- W2569159701 cites W1978270439 @default.
- W2569159701 cites W1978678714 @default.
- W2569159701 cites W1980069790 @default.
- W2569159701 cites W1980544777 @default.
- W2569159701 cites W1980611128 @default.
- W2569159701 cites W1981870037 @default.
- W2569159701 cites W1982159478 @default.
- W2569159701 cites W1983414601 @default.
- W2569159701 cites W1984588909 @default.
- W2569159701 cites W1985792696 @default.
- W2569159701 cites W1986258151 @default.
- W2569159701 cites W1988896491 @default.
- W2569159701 cites W1989880837 @default.
- W2569159701 cites W1991073331 @default.
- W2569159701 cites W1991640360 @default.
- W2569159701 cites W1993315768 @default.
- W2569159701 cites W1995904230 @default.
- W2569159701 cites W1996664630 @default.
- W2569159701 cites W1997082999 @default.
- W2569159701 cites W1998588892 @default.
- W2569159701 cites W1998666504 @default.
- W2569159701 cites W1998839307 @default.
- W2569159701 cites W1999570717 @default.
- W2569159701 cites W2000065998 @default.
- W2569159701 cites W2000632234 @default.
- W2569159701 cites W2000787312 @default.
- W2569159701 cites W2001153857 @default.
- W2569159701 cites W2001280594 @default.
- W2569159701 cites W2001422785 @default.
- W2569159701 cites W2001840249 @default.
- W2569159701 cites W2001957465 @default.
- W2569159701 cites W2002591374 @default.
- W2569159701 cites W2002762216 @default.
- W2569159701 cites W2002826447 @default.
- W2569159701 cites W2004196309 @default.
- W2569159701 cites W2005138952 @default.
- W2569159701 cites W2006816193 @default.
- W2569159701 cites W2008681067 @default.
- W2569159701 cites W2010317083 @default.
- W2569159701 cites W2010589712 @default.
- W2569159701 cites W2011582754 @default.
- W2569159701 cites W2012112479 @default.
- W2569159701 cites W2014024853 @default.
- W2569159701 cites W2015683287 @default.
- W2569159701 cites W2018809578 @default.
- W2569159701 cites W2019490196 @default.
- W2569159701 cites W2021269902 @default.
- W2569159701 cites W2021656221 @default.
- W2569159701 cites W2022430355 @default.
- W2569159701 cites W2022637056 @default.
- W2569159701 cites W2027303551 @default.
- W2569159701 cites W2028473523 @default.
- W2569159701 cites W2029248129 @default.
- W2569159701 cites W2031424394 @default.
- W2569159701 cites W2033158962 @default.