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- W2569206125 abstract "Abstract The use of mammalian cells for therapeutic applications is finding its way into modern medicine. However, modification or “training” of cells to make them suitable for a specific application remains complex. By envisioning a chemical toolbox that enables specific, but straight-forward and generic cellular functionalization, we investigated how membrane-receptor (pre)targeting could be combined with supramolecular host-guest interactions based on β-cyclodextrin (CD) and adamantane (Ad). The feasibility of this approach was studied in cells with membranous overexpression of the chemokine receptor 4 (CXCR4). By combining specific targeting of CXCR4, using an adamantane (Ad)-functionalized Ac-TZ14011 peptide (guest; K D = 56 nM), with multivalent host molecules that entailed fluorescent β-CD-Poly(isobutylene- alt -maleic-anhydride)-polymers with different fluorescent colors and number of functionalities, host-guest cell-surface modifications could be studied in detail. A second set of Ad-functionalized entities enabled introduction of additional surface functionalities. In addition, the attraction between CD and Ad could be used to drive cell-cell interactions. Combined we have shown that supramolecular interactions, that are based on specific targeting of an overexpressed membrane-receptor, allow specific and stable, yet reversible, surface functionalization of viable cells and how this approach can be used to influence the interaction between cells and their surroundings." @default.
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- W2569206125 date "2017-01-06" @default.
- W2569206125 modified "2023-10-01" @default.
- W2569206125 title "Obtaining control of cell surface functionalizations via Pre-targeting and Supramolecular host guest interactions" @default.
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- W2569206125 doi "https://doi.org/10.1038/srep39908" @default.
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