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• W2569228435 abstract "Mutations or translocations in driver genes of lung cancer such as EGFR or ALK are important treatment targets for advanced lung cancer. These alterations are present mainly in never-smokers. Exposure to environmental tobacco smoke (ETS) might provide some explanation to the presence of such genetic traits. Furthermore, ETS exposure might have a different effect should occur at home in adult life, during childhood, or at work. We aim to know if ETS exposure is associated with EGFR mutations or ALK alterations in a huge sample of never smoking lung cancer cases. We recruited never smoking lung cancer cases diagnosed consecutively in 9 Spanish Hospitals since 2011. We collected extensive information on different lifestyle activities and also measured residential radon exposure. Cases had to be older than 30 years with no upper age limit and with no previous history of cancer. A never smoker was defined as: 1) an individual who smoked less than 1 daily cigarette for no more than 6 months or, 2) no more than 100 cigarettes smoked in lifetime. EGFR mutations and ALK alterations were determined using standard procedures. Logistic regressions were performed to analyze the influence of exposure to ETS in different settings (adult life at home, at work or during childhood). The dependent variables were EGFR mutation (of any type) or not, or ALK translocation (present/absent). Results were adjusted by age, gender and residential radon exposure. We included 389 never smoking lung cancer cases. 80.5% were females and the median age was 71 and the interquartilic range 61-78 years. 246 patients had EGFR determined (63.2% of the total) and of them, EGFR was mutated in 43%. ALK status was determined in 97 patients (24.9% of the total), and was positive in 16 patients (16.5%). Living at home with a smoker for more than 20 years was not associated with EGFR mutation or ALK translocation, and the same occurred for being exposed to ETS at work. When exposure to ETS in childhood (before 16) was considered, we observed that those exposed to ETS had an OR of EGFR mutation of 0.57 (95%CI 0.31-1.05; p= 0.07). No association was observed for ALK translocation. These results suggest that exposure to environmental tobacco smoke in childhood might reduce the chance of EGFR mutation in never smokers with lung cancer. This observation would add more evidence to avoid exposure to ETS in any time of life. Funding: ISCIII/PI13/01765/Cofinanciado FEDER" @default.
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• W2569228435 date "2017-01-01" @default.
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• W2569228435 title "P1.01-002 Environmental Tobacco Smoke Exposure and EGFR Mutations/ALK Translocation in Never Smokers. A Multicenter Study in Spanish Never-Smokers" @default.
• W2569228435 doi "https://doi.org/10.1016/j.jtho.2016.11.526" @default.
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