FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2569228525> ?p ?o ?g. }

• W2569228525 endingPage "1677" @default.
• W2569228525 startingPage "1668" @default.
• W2569228525 abstract "Zonula occludens-1 (ZO-1) is a submembrane scaffolding protein that may display proinvasive functions when it relocates from tight junctions into the cytonuclear compartment. This article examines the functional involvement of ZO-1 in CXCL8/IL-8 chemokine expression in lung and breast tumor cells. ZO-1 small interfering RNA and cDNA transfection experiments emphasized regulation of CXCL8/IL-8 expression via a cytonuclear pool of ZO-1. Luciferase reporter assays highlighted a 173-bp region of CXCL8/IL-8 promoter that responded to ZO-1. Moreover, by using mutated promoter constructs, we identified a NF-κB site as critical in this activation. Furthermore, NF-κB pathway signaling analysis revealed both IκBα and p65 phosphorylation in ZO-1-overexpressing cells, and subsequent p65 silencing validated its requirement for CXCL8/IL-8 induction. Investigation of the functional implication of this regulatory axis next showed the proangiogenic activity of ZO-1 in both ex vivo and in vivo angiogenesis assays. Finally, we found that non–small-cell lung carcinoma that presented a cytonuclear ZO-1 pattern was significantly more angiogenic that that without detectable cytonuclear ZO-1 expression. Taken together, our results demonstrate that ZO-1 regulates CXCL8/IL-8 expression via the NF-κB signaling pathway and its p65 subunit, which subsequently modulates the transcription of IL-8. We also provide evidence of a newly identified regulatory pathway that could promote angiogenesis. Thus, our results support the concept that the ZO-1 shuttle from the cell junction to the cytonuclear compartment may affect both the intrinsic invasive properties of tumor cells and the establishment of the protumoral microenvironment. —Lesage, J., Suarez-Carmona, M., Neyrinck-Leglantier, D., Grelet, S., Blacher, S., Hunziker, W., Birembaut, P., Noël, A., Nawrocki-Raby, B., Gilles, C., Polette, M. Zonula occludens-1/NF-κB/CXCL8: a new regulatory axis for tumor angiogenesis. FASEB J. 31, 1678–1688 (2017) www.fasebj.org" @default.
• W2569228525 created "2017-01-13" @default.
• W2569228525 creator A5031434363 @default.
• W2569228525 creator A5041860565 @default.
• W2569228525 creator A5043797392 @default.
• W2569228525 creator A5047035945 @default.
• W2569228525 creator A5051374037 @default.
• W2569228525 creator A5053186841 @default.
• W2569228525 creator A5054329378 @default.
• W2569228525 creator A5058601352 @default.
• W2569228525 creator A5065303230 @default.
• W2569228525 creator A5065652153 @default.
• W2569228525 creator A5084744120 @default.
• W2569228525 date "2017-01-17" @default.
• W2569228525 modified "2023-09-25" @default.
• W2569228525 title "Zonula occludens‐1/NF‐κB/CXCL8: a new regulatory axis for tumor angiogenesis" @default.
• W2569228525 cites W1486740674 @default.
• W2569228525 cites W1518308640 @default.
• W2569228525 cites W1526747357 @default.
• W2569228525 cites W1573683888 @default.
• W2569228525 cites W1824927203 @default.
• W2569228525 cites W1889866591 @default.
• W2569228525 cites W1964081206 @default.
• W2569228525 cites W1969103696 @default.
• W2569228525 cites W1973033965 @default.
• W2569228525 cites W1979870993 @default.
• W2569228525 cites W1980202624 @default.
• W2569228525 cites W1991137546 @default.
• W2569228525 cites W1992499848 @default.
• W2569228525 cites W1997196951 @default.
• W2569228525 cites W1998986106 @default.
• W2569228525 cites W2003409252 @default.
• W2569228525 cites W2009775095 @default.
• W2569228525 cites W2012664772 @default.
• W2569228525 cites W2017729871 @default.
• W2569228525 cites W2018567418 @default.
• W2569228525 cites W2037481900 @default.
• W2569228525 cites W2040645020 @default.
• W2569228525 cites W2041760097 @default.
• W2569228525 cites W2041862485 @default.
• W2569228525 cites W2042198997 @default.
• W2569228525 cites W2052908553 @default.
• W2569228525 cites W2056088187 @default.
• W2569228525 cites W2062344492 @default.
• W2569228525 cites W2062570896 @default.
• W2569228525 cites W2073383111 @default.
• W2569228525 cites W2086627696 @default.
• W2569228525 cites W2091720415 @default.
• W2569228525 cites W2092021793 @default.
• W2569228525 cites W2093472132 @default.
• W2569228525 cites W2094845673 @default.
• W2569228525 cites W2102517990 @default.
• W2569228525 cites W2110567472 @default.
• W2569228525 cites W2111441107 @default.
• W2569228525 cites W2111689605 @default.
• W2569228525 cites W2117412547 @default.
• W2569228525 cites W2130801530 @default.
• W2569228525 cites W2135377650 @default.
• W2569228525 cites W2143372911 @default.
• W2569228525 cites W2145619332 @default.
• W2569228525 cites W2145921423 @default.
• W2569228525 cites W2150046698 @default.
• W2569228525 cites W2155579605 @default.
• W2569228525 cites W2167235505 @default.
• W2569228525 cites W2327223530 @default.
• W2569228525 cites W4251580293 @default.
• W2569228525 doi "https://doi.org/10.1096/fj.201600890r" @default.
• W2569228525 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28057697" @default.
• W2569228525 hasPublicationYear "2017" @default.
• W2569228525 type Work @default.
• W2569228525 sameAs 2569228525 @default.
• W2569228525 citedByCount "22" @default.
• W2569228525 countsByYear W25692285252017 @default.
• W2569228525 countsByYear W25692285252018 @default.
• W2569228525 countsByYear W25692285252019 @default.
• W2569228525 countsByYear W25692285252020 @default.
• W2569228525 countsByYear W25692285252021 @default.
• W2569228525 countsByYear W25692285252022 @default.
• W2569228525 countsByYear W25692285252023 @default.
• W2569228525 crossrefType "journal-article" @default.
• W2569228525 hasAuthorship W2569228525A5031434363 @default.
• W2569228525 hasAuthorship W2569228525A5041860565 @default.
• W2569228525 hasAuthorship W2569228525A5043797392 @default.
• W2569228525 hasAuthorship W2569228525A5047035945 @default.
• W2569228525 hasAuthorship W2569228525A5051374037 @default.
• W2569228525 hasAuthorship W2569228525A5053186841 @default.
• W2569228525 hasAuthorship W2569228525A5054329378 @default.
• W2569228525 hasAuthorship W2569228525A5058601352 @default.
• W2569228525 hasAuthorship W2569228525A5065303230 @default.
• W2569228525 hasAuthorship W2569228525A5065652153 @default.
• W2569228525 hasAuthorship W2569228525A5084744120 @default.
• W2569228525 hasConcept C104317684 @default.
• W2569228525 hasConcept C119056186 @default.
• W2569228525 hasConcept C203014093 @default.
• W2569228525 hasConcept C22615655 @default.
• W2569228525 hasConcept C2778690821 @default.
• W2569228525 hasConcept C2780394083 @default.
• W2569228525 hasConcept C502942594 @default.

• next