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- W2569232015 abstract "155 Background: The transarterial chemoembolization (TACE) and the radiofrequency ablation (RFA) are the keystones of interventional therapy of primary and secondary liver malignancies in oncology. A compromised liver function may be a relative contraindication to these therapies. Child-Pugh liver scoring system is widely used to exclude patients with low liver function. The indocyanine green (ICG) retention rate at 15 min. (ICGR15) is a frequently used liver function test in liver surgery, however it is not widely available. The quantification of dynamic cholescintigraphy and the calculation of hepatic extraction fraction (HEF) describes specifically a functional efficiency of the liver parenchyma. Methods: We retrospectively studied 107 patients with primary or secondary liver malignancies who underwent TACE or RFA between February 2005 and February 2012. ICG test and dynamic cholescintigraphy and Child-Pugh score were assessed before the procedure. The comparison of relative frequencies of categories was performed by binomial test (independent testing) or by McNemar’s test (paired design). The association in occurrence of different categories was tested by the help of Fisher’s exact test. Results: The comparison of categorized outcomes of ICGR15 and HEF examination revealed high degree of agreement between these techniques (p = 0.773). The statistically significant similarity in the outcome of both methods was also proved by the analysis of contingency tables. 81% of tested samples obtained the same scoring by both approaches. Clinically important discrepancies between these methods were rare and were not observed in the two extreme categories, i.e. normal and very low liver function. Conclusions: The ICGR15 correlates well with the HEF in liver function assessment. Thus either method can be used in patients who are to undergo liver directed therapies when the assessment by Child-Pugh score is not sufficient enough." @default.
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- W2569232015 date "2013-02-01" @default.
- W2569232015 modified "2023-09-25" @default.
- W2569232015 title "The liver function assessment: The indocyanine green retention in correlation with the cholescintigraphic measurement—Retrospective validation study in 107 patients with liver malignancies." @default.
- W2569232015 doi "https://doi.org/10.1200/jco.2013.31.4_suppl.155" @default.
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