FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2569258381> ?p ?o ?g. }

• W2569258381 endingPage "2113" @default.
• W2569258381 startingPage "2104" @default.
• W2569258381 abstract "Nitric oxide (NO) occurs naturally in mammalian biochemistry as a critical signaling molecule and exhibits antithrombotic, antibacterial, and wound-healing properties. NO-forming biodegradable polymers have been utilized in the development of antithrombotic or antibacterial materials for biointerfacial applications, including tissue engineering and the fabrication of erodible coatings for medical devices such as stents. Use of such NO-forming polymers has frequently been constrained by short-term release or limited NO storage capacity and has led to the pursuit of new materials with improved NO release function. Herein, we report the development of an NO-releasing bioerodible coating prepared from poly[bis(3-mercapto-3-methylbut-1-yl glycinyl)phosphazene] (POP-Gly-MMB), a polyphosphazene based on glycine and the naturally occurring tertiary thiol 3-mercapto-3-methylbutan-1-ol (MMB). To evaluate the NO release properties of this material, the thiolated polymer POP-Gly-MMB-SH was applied as a coating to glass substrates and subsequently converted to the NO-forming S-nitrosothiol (RSNO) derivative (POP-Gly-MMB-NO) by immersion in a mixture of tert-butyl nitrite (t-BuONO) and pentane. NO release flux from the coated substrates was determined by chemiluminescence-based NO measurement and was found to remain in a physiologically relevant range for up to 2 weeks (6.5–0.090 nmol of NO·min–1·cm–2) when immersed in pH 7.4 phosphate-buffered saline (PBS) at 37 °C. Furthermore, the coating exhibited an overall NO storage capacity of 0.89 ± 0.09 mmol·g–1 (4.3 ± 0.6 μmol·cm–2). Erosion of POP-Gly-MMB-NO in PBS at 37 °C over 6 weeks results in 14% mass loss, and time-of-flight mass spectrometry (TOF-MS) was used to characterize the organic products of hydrolytic degradation as glycine, MMB, and several related esters. The comparatively long-term NO release and high storage capacity of POP-Gly-MMB-NO coatings suggest potential as a source of therapeutic NO for biomedical applications." @default.
• W2569258381 created "2017-01-13" @default.
• W2569258381 creator A5009965717 @default.
• W2569258381 creator A5040126140 @default.
• W2569258381 creator A5090646799 @default.
• W2569258381 creator A5091062721 @default.
• W2569258381 date "2017-01-09" @default.
• W2569258381 modified "2023-09-27" @default.
• W2569258381 title "Sustained Nitric Oxide Release from a Tertiary <i>S</i>-Nitrosothiol-based Polyphosphazene Coating" @default.
• W2569258381 cites W1479760463 @default.
• W2569258381 cites W1480814951 @default.
• W2569258381 cites W1537911503 @default.
• W2569258381 cites W1560571961 @default.
• W2569258381 cites W184726500 @default.
• W2569258381 cites W1964415844 @default.
• W2569258381 cites W1967225427 @default.
• W2569258381 cites W1972432360 @default.
• W2569258381 cites W1972812573 @default.
• W2569258381 cites W1973433631 @default.
• W2569258381 cites W1973574872 @default.
• W2569258381 cites W1974852925 @default.
• W2569258381 cites W1989134564 @default.
• W2569258381 cites W1991597890 @default.
• W2569258381 cites W1993601025 @default.
• W2569258381 cites W1993938691 @default.
• W2569258381 cites W2002777248 @default.
• W2569258381 cites W2004368332 @default.
• W2569258381 cites W2010554317 @default.
• W2569258381 cites W2010640739 @default.
• W2569258381 cites W2014066034 @default.
• W2569258381 cites W2014649832 @default.
• W2569258381 cites W2019962291 @default.
• W2569258381 cites W2021046766 @default.
• W2569258381 cites W2023275162 @default.
• W2569258381 cites W2026954356 @default.
• W2569258381 cites W2032950343 @default.
• W2569258381 cites W2037981066 @default.
• W2569258381 cites W2040856583 @default.
• W2569258381 cites W2042784234 @default.
• W2569258381 cites W2050780578 @default.
• W2569258381 cites W2052563420 @default.
• W2569258381 cites W2057235018 @default.
• W2569258381 cites W2059930779 @default.
• W2569258381 cites W2060841827 @default.
• W2569258381 cites W2063683385 @default.
• W2569258381 cites W2064016001 @default.
• W2569258381 cites W2064549275 @default.
• W2569258381 cites W2068122984 @default.
• W2569258381 cites W2068821692 @default.
• W2569258381 cites W2070165290 @default.
• W2569258381 cites W2071264150 @default.
• W2569258381 cites W2071980319 @default.
• W2569258381 cites W2076041064 @default.
• W2569258381 cites W2082645936 @default.
• W2569258381 cites W2092145002 @default.
• W2569258381 cites W2103815234 @default.
• W2569258381 cites W2119095639 @default.
• W2569258381 cites W2140402513 @default.
• W2569258381 cites W2148799738 @default.
• W2569258381 cites W2150977308 @default.
• W2569258381 cites W2295005352 @default.
• W2569258381 cites W2317457447 @default.
• W2569258381 cites W2320134209 @default.
• W2569258381 cites W2321953134 @default.
• W2569258381 cites W2410225858 @default.
• W2569258381 cites W2424314688 @default.
• W2569258381 cites W2951769065 @default.
• W2569258381 doi "https://doi.org/10.1021/acsami.6b12888" @default.
• W2569258381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28068065" @default.
• W2569258381 hasPublicationYear "2017" @default.
• W2569258381 type Work @default.
• W2569258381 sameAs 2569258381 @default.
• W2569258381 citedByCount "33" @default.
• W2569258381 countsByYear W25692583812017 @default.
• W2569258381 countsByYear W25692583812018 @default.
• W2569258381 countsByYear W25692583812019 @default.
• W2569258381 countsByYear W25692583812020 @default.
• W2569258381 countsByYear W25692583812021 @default.
• W2569258381 countsByYear W25692583812022 @default.
• W2569258381 countsByYear W25692583812023 @default.
• W2569258381 crossrefType "journal-article" @default.
• W2569258381 hasAuthorship W2569258381A5009965717 @default.
• W2569258381 hasAuthorship W2569258381A5040126140 @default.
• W2569258381 hasAuthorship W2569258381A5090646799 @default.
• W2569258381 hasAuthorship W2569258381A5091062721 @default.
• W2569258381 hasConcept C127413603 @default.
• W2569258381 hasConcept C13965031 @default.
• W2569258381 hasConcept C159985019 @default.
• W2569258381 hasConcept C171250308 @default.
• W2569258381 hasConcept C178790620 @default.
• W2569258381 hasConcept C185592680 @default.
• W2569258381 hasConcept C192562407 @default.
• W2569258381 hasConcept C2779019844 @default.
• W2569258381 hasConcept C2779961764 @default.
• W2569258381 hasConcept C2781448156 @default.
• W2569258381 hasConcept C42360764 @default.
• W2569258381 hasConcept C521977710 @default.
• W2569258381 hasConceptScore W2569258381C127413603 @default.

• next