FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2569349299> ?p ?o ?g. }

• W2569349299 endingPage "e5679" @default.
• W2569349299 startingPage "e5679" @default.
• W2569349299 abstract "Prostate cancer (PC) is a common neoplasm, and metastatic PC remains incurable. The study aims to screen key microRNAs (miRNAs) and transcription factors (TFs) involved in PC. The miRNA expression profile dataset (GSE45604) was downloaded from Gene Expression Omnibus database, including 50 PC and 10 normal specimens. Differentially expressed miRNAs (DEmiRNAs) were identified through limma package in R, and DEmiRNA–DEmiRNA co-regulation network was constructed based on the number of co-regulated target genes. Functional enrichment analysis of co-regulated target genes was performed using clusterProfiler package in R, and miRNA interactions sharing at least 1 functional term were used to construct a DEmiRNA–DEmiRNA functional synergistic network (MFSN). Based on Transcriptional Regulatory Element Database, cancer-related TFs which were co-regulated by DEmiRNAs were utilized to construct a DEmiRNA–TF regulation network. A total of 66 DEmiRNAs were identified, including 7 up-regulated miRNAs with 18,642 target genes and 59 down-regulated miRNAs with 130,694 target genes. Then, the DEmiRNA–DEmiRNA co-regulation network was constructed, including 66 DEmiRNAs and 2024 co-regulation relationships. In MFSN, hsa-miR-1184, hsa-miR-1207-5p, and hsa-miR-24 had significant functional synergistic relationships. The DEmiRNA–TF network contained 6 up-regulated DEmiRNAs and 4 of them were highlighted, as hsa-miR-1184, hsa-miR-1207-5p, hsa-miR-182, and hsa-miR-183. In subnetwork of the 4 miRNAs, peroxisome proliferative activated receptor, alpha (PPARA) and cyclic AMP-responsive element modulator (CREM) were the critical regulated TFs. Four up-regulated miRNAs (hsa-miR-1207-5p, hsa-miR-1184, hsa-miR-182, and hsa-miR-183) and 2 TFs (PPARA and CREM) were identified as key regulators in PC progression. The above 4 miRNAs might participate in PC progression by targeting PPARA and CREM." @default.
• W2569349299 created "2017-01-13" @default.
• W2569349299 creator A5032526310 @default.
• W2569349299 creator A5035548891 @default.
• W2569349299 creator A5051486069 @default.
• W2569349299 creator A5055795347 @default.
• W2569349299 creator A5061642965 @default.
• W2569349299 date "2017-01-01" @default.
• W2569349299 modified "2023-10-16" @default.
• W2569349299 title "Screening the key microRNAs and transcription factors in prostate cancer based on microRNA functional synergistic relationships" @default.
• W2569349299 cites W1914047148 @default.
• W2569349299 cites W1976029219 @default.
• W2569349299 cites W1980265915 @default.
• W2569349299 cites W1996487270 @default.
• W2569349299 cites W2009216661 @default.
• W2569349299 cites W2017262213 @default.
• W2569349299 cites W2017742278 @default.
• W2569349299 cites W2025895935 @default.
• W2569349299 cites W2026682712 @default.
• W2569349299 cites W2027406112 @default.
• W2569349299 cites W2035618305 @default.
• W2569349299 cites W2037715998 @default.
• W2569349299 cites W2038873075 @default.
• W2569349299 cites W2048603557 @default.
• W2569349299 cites W2050869737 @default.
• W2569349299 cites W2056230262 @default.
• W2569349299 cites W2056566784 @default.
• W2569349299 cites W2062786725 @default.
• W2569349299 cites W2078899492 @default.
• W2569349299 cites W2081098333 @default.
• W2569349299 cites W2082299481 @default.
• W2569349299 cites W2102395431 @default.
• W2569349299 cites W2112192177 @default.
• W2569349299 cites W2118529304 @default.
• W2569349299 cites W2120522615 @default.
• W2569349299 cites W2135810600 @default.
• W2569349299 cites W2139088550 @default.
• W2569349299 cites W2144855474 @default.
• W2569349299 cites W2152182795 @default.
• W2569349299 cites W2154877324 @default.
• W2569349299 cites W2159181129 @default.
• W2569349299 cites W2159675211 @default.
• W2569349299 cites W2166898290 @default.
• W2569349299 cites W2170187210 @default.
• W2569349299 cites W2170341165 @default.
• W2569349299 cites W2171322586 @default.
• W2569349299 doi "https://doi.org/10.1097/md.0000000000005679" @default.
• W2569349299 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5228663" @default.
• W2569349299 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28072703" @default.
• W2569349299 hasPublicationYear "2017" @default.
• W2569349299 type Work @default.
• W2569349299 sameAs 2569349299 @default.
• W2569349299 citedByCount "16" @default.
• W2569349299 countsByYear W25693492992017 @default.
• W2569349299 countsByYear W25693492992018 @default.
• W2569349299 countsByYear W25693492992019 @default.
• W2569349299 countsByYear W25693492992020 @default.
• W2569349299 countsByYear W25693492992021 @default.
• W2569349299 countsByYear W25693492992022 @default.
• W2569349299 countsByYear W25693492992023 @default.
• W2569349299 crossrefType "journal-article" @default.
• W2569349299 hasAuthorship W2569349299A5032526310 @default.
• W2569349299 hasAuthorship W2569349299A5035548891 @default.
• W2569349299 hasAuthorship W2569349299A5051486069 @default.
• W2569349299 hasAuthorship W2569349299A5055795347 @default.
• W2569349299 hasAuthorship W2569349299A5061642965 @default.
• W2569349299 hasBestOaLocation W25693492991 @default.
• W2569349299 hasConcept C104317684 @default.
• W2569349299 hasConcept C121608353 @default.
• W2569349299 hasConcept C145059251 @default.
• W2569349299 hasConcept C150194340 @default.
• W2569349299 hasConcept C165864922 @default.
• W2569349299 hasConcept C2780192828 @default.
• W2569349299 hasConcept C502942594 @default.
• W2569349299 hasConcept C54355233 @default.
• W2569349299 hasConcept C60644358 @default.
• W2569349299 hasConcept C67339327 @default.
• W2569349299 hasConcept C70721500 @default.
• W2569349299 hasConcept C71924100 @default.
• W2569349299 hasConcept C86339819 @default.
• W2569349299 hasConcept C86803240 @default.
• W2569349299 hasConceptScore W2569349299C104317684 @default.
• W2569349299 hasConceptScore W2569349299C121608353 @default.
• W2569349299 hasConceptScore W2569349299C145059251 @default.
• W2569349299 hasConceptScore W2569349299C150194340 @default.
• W2569349299 hasConceptScore W2569349299C165864922 @default.
• W2569349299 hasConceptScore W2569349299C2780192828 @default.
• W2569349299 hasConceptScore W2569349299C502942594 @default.
• W2569349299 hasConceptScore W2569349299C54355233 @default.
• W2569349299 hasConceptScore W2569349299C60644358 @default.
• W2569349299 hasConceptScore W2569349299C67339327 @default.
• W2569349299 hasConceptScore W2569349299C70721500 @default.
• W2569349299 hasConceptScore W2569349299C71924100 @default.
• W2569349299 hasConceptScore W2569349299C86339819 @default.
• W2569349299 hasConceptScore W2569349299C86803240 @default.
• W2569349299 hasIssue "1" @default.
• W2569349299 hasLocation W25693492991 @default.
• W2569349299 hasLocation W25693492992 @default.

• next