Matches in SemOpenAlex for { <https://semopenalex.org/work/W2569373054> ?p ?o ?g. }
- W2569373054 endingPage "70" @default.
- W2569373054 startingPage "63" @default.
- W2569373054 abstract "Damage biomarkers may identify mechanisms and sites of acute kidney injury (AKI). However, the utility of novel AKI biomarkers differs by context, and their utility for monitoring treatment of AKI is unknown. We hypothesized that selected AKI biomarkers would facilitate monitoring of mechanism-specific treatment. We examined this using a panel of biomarkers to monitor cisplatin-induced AKI treatment with alpha-lipoic acid (α-LA) that has previously been demonstrated to ameliorate cisplatin induced AKI. AKI was induced in male Sprague Dawley rats using cisplatin (6 mg/kg) in the presence or absence of a single dose of α-LA (100 mg/kg). A panel of 12 urinary kidney damage biomarkers (Cystatin C, NGAL albumin, alpha-1-acid glycoprotein, clusterin, KIM-1, osteopontin, total protein, cytochrome C, epidermal growth factor, interleukin-18 and malondialdehyde was examined as well as histological injury, serum creatinine and cystatin C, and clinical parameters. Cisplatin treatment modified all parameters, except interleukin-18 and malondialdehyde, with each parameter demonstrating a different temporal profile. α-LA treatment attenuated renal tubular injury scores (P < 0.05), decreased peak serum creatinine (p = 0.004) and cystatin C (p = 0.04), and urinary damage biomarkers of proximal tubular injury (Cystatin C, NGAL, albumin, and alpha-1-acid glycoprotein). Other urinary biomarkers were not modified. Neither α-LA alone, nor the cisplatin vehicle (DMSO) modified biomarker profiles. α-LA treatment ameliorated cisplatin-induced AKI. Protection was demonstrated by reduced structural damage, improved glomerular filtration and reduced excretion of urinary biomarkers of proximal tubular damage. Effective treatment of AKI can be monitored by site and perhaps by mechanism-specific kidney damage biomarkers." @default.
- W2569373054 created "2017-01-13" @default.
- W2569373054 creator A5040371388 @default.
- W2569373054 creator A5041049280 @default.
- W2569373054 creator A5056000487 @default.
- W2569373054 creator A5071057018 @default.
- W2569373054 creator A5078362833 @default.
- W2569373054 date "2017-02-01" @default.
- W2569373054 modified "2023-10-14" @default.
- W2569373054 title "Monitoring treatment of acute kidney injury with damage biomarkers" @default.
- W2569373054 cites W114992312 @default.
- W2569373054 cites W1579301857 @default.
- W2569373054 cites W1593328756 @default.
- W2569373054 cites W1600507784 @default.
- W2569373054 cites W1965696818 @default.
- W2569373054 cites W1970454678 @default.
- W2569373054 cites W1971948259 @default.
- W2569373054 cites W1975229945 @default.
- W2569373054 cites W1975299519 @default.
- W2569373054 cites W1975623216 @default.
- W2569373054 cites W1977476783 @default.
- W2569373054 cites W1983965827 @default.
- W2569373054 cites W1990363063 @default.
- W2569373054 cites W1990966209 @default.
- W2569373054 cites W1993998482 @default.
- W2569373054 cites W1997922823 @default.
- W2569373054 cites W1998899890 @default.
- W2569373054 cites W1999158749 @default.
- W2569373054 cites W2000432883 @default.
- W2569373054 cites W2003418600 @default.
- W2569373054 cites W2008232708 @default.
- W2569373054 cites W2013815595 @default.
- W2569373054 cites W2014921406 @default.
- W2569373054 cites W2026942191 @default.
- W2569373054 cites W2031292272 @default.
- W2569373054 cites W2047937904 @default.
- W2569373054 cites W2054193250 @default.
- W2569373054 cites W2055618915 @default.
- W2569373054 cites W2061082542 @default.
- W2569373054 cites W2068979787 @default.
- W2569373054 cites W2077574200 @default.
- W2569373054 cites W2085624687 @default.
- W2569373054 cites W2086258375 @default.
- W2569373054 cites W2088550590 @default.
- W2569373054 cites W2090852896 @default.
- W2569373054 cites W2092271268 @default.
- W2569373054 cites W2101412937 @default.
- W2569373054 cites W2101792171 @default.
- W2569373054 cites W2111062515 @default.
- W2569373054 cites W2114386003 @default.
- W2569373054 cites W2118674385 @default.
- W2569373054 cites W2119022117 @default.
- W2569373054 cites W2119194499 @default.
- W2569373054 cites W2123360072 @default.
- W2569373054 cites W2126098543 @default.
- W2569373054 cites W2145560719 @default.
- W2569373054 cites W2150198765 @default.
- W2569373054 cites W2155970862 @default.
- W2569373054 cites W2156813826 @default.
- W2569373054 cites W2164819474 @default.
- W2569373054 cites W2171933867 @default.
- W2569373054 doi "https://doi.org/10.1016/j.toxlet.2017.01.001" @default.
- W2569373054 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28065798" @default.
- W2569373054 hasPublicationYear "2017" @default.
- W2569373054 type Work @default.
- W2569373054 sameAs 2569373054 @default.
- W2569373054 citedByCount "19" @default.
- W2569373054 countsByYear W25693730542017 @default.
- W2569373054 countsByYear W25693730542018 @default.
- W2569373054 countsByYear W25693730542019 @default.
- W2569373054 countsByYear W25693730542020 @default.
- W2569373054 countsByYear W25693730542021 @default.
- W2569373054 countsByYear W25693730542023 @default.
- W2569373054 crossrefType "journal-article" @default.
- W2569373054 hasAuthorship W2569373054A5040371388 @default.
- W2569373054 hasAuthorship W2569373054A5041049280 @default.
- W2569373054 hasAuthorship W2569373054A5056000487 @default.
- W2569373054 hasAuthorship W2569373054A5071057018 @default.
- W2569373054 hasAuthorship W2569373054A5078362833 @default.
- W2569373054 hasConcept C126322002 @default.
- W2569373054 hasConcept C126894567 @default.
- W2569373054 hasConcept C159641895 @default.
- W2569373054 hasConcept C185592680 @default.
- W2569373054 hasConcept C190283241 @default.
- W2569373054 hasConcept C2776151105 @default.
- W2569373054 hasConcept C2776694085 @default.
- W2569373054 hasConcept C2778239845 @default.
- W2569373054 hasConcept C2778401633 @default.
- W2569373054 hasConcept C2778653478 @default.
- W2569373054 hasConcept C2779476363 @default.
- W2569373054 hasConcept C2779548226 @default.
- W2569373054 hasConcept C2780306776 @default.
- W2569373054 hasConcept C2780412452 @default.
- W2569373054 hasConcept C2780472472 @default.
- W2569373054 hasConcept C2781197716 @default.
- W2569373054 hasConcept C55493867 @default.
- W2569373054 hasConcept C71924100 @default.
- W2569373054 hasConcept C77411442 @default.