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- W2569563580 abstract "Numerous yeasts produce toxic compounds to fight the competitors. Such compounds include small molecules (like antibiotics), antibiotic peptides, and also larger proteins, including killer toxins. Their ability to affect the cell depends on the host factors modulating the killing activity. Here we describe a robotics-based method to advance the genome-wide screening for the host factors affecting sensitivity of budding yeast to the killer toxins using the K2 system as the model. We demonstrate that arraying the mutant library on the agar plates containing the K2 killer toxinproducing strain and/or purified toxin (“survival” assay) increases the sensitivity and speed of the screen and decreases the costs compared to the traditional “killer” assay. We show the applicability of a new screening method of searching for the host factors using a killer strain isolated from agricultural plant environment. In addition, the “survival” assay allows identification of previously undetected factors that could be the “missing links” in the pathways of toxininduced cellular responses." @default.
- W2569563580 created "2017-01-13" @default.
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- W2569563580 date "2017-01-05" @default.
- W2569563580 modified "2023-10-16" @default.
- W2569563580 title "A quick and reliable method for genome-wide host factor screening of Saccharomyces cerevisiae killer toxins" @default.
- W2569563580 doi "https://doi.org/10.6001/biologija.v62i4.3413" @default.
- W2569563580 hasPublicationYear "2017" @default.
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