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- W2569659322 abstract "Young patients diagnosed as non-small cell lung cancer (NSCLC) is rare. Little is known for its genomic alterations and survival. This study retrospectively evaluated the genomic alterations, treatment and prognosis with NSCLC in our institution between January 2009 and July 2014. All patients were examined for EGFR, KRAS, NRAS, PIK3CA, BRAF, HER2 mutations and ALK, ROS1, RET fusion genes based on reverse transcription PCR. The Kaplan-Meier method was used to estimate survival and comparison using the log-rank test. Totally, 54 were with age under 40 years old among 640 patients. Among the 640 patients, three hundred and fifty eight patients were with identified genomic alterations with frequency of 55.9 %. The frequencies of genomic alterations in younger and older were 68.5% and 54.8%, respectively (P=0.05). The frequencies difference between younger and older existed in fusions genes (22.2% vs.4.1%, P<0.001), but not mutations genes (46.3% vs.45.6%, P=0.92). There was a trend of shorter recurrence free survival in younger than older (35.2 vs.43.8 months, P=0.050), while no survival difference was found between younger and older (50.2 vs 51.4 months, P=0.112). We concluded that younger age of NSCLC is associated with a trend of increased of harboring targeted genes and mainly with difference of fusion genes. An inferior overall survival existed in younger than older." @default.
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- W2569659322 date "2017-01-01" @default.
- W2569659322 modified "2023-09-25" @default.
- W2569659322 title "P1.02-069 Genomic Alterations and Survival in Young Patients under 40 Years with Completely Resected Non-Small Cell Lung Cancer" @default.
- W2569659322 doi "https://doi.org/10.1016/j.jtho.2016.11.653" @default.
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