FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W256976557> ?p ?o ?g. }

• W256976557 endingPage "7" @default.
• W256976557 startingPage "52" @default.
• W256976557 abstract "To identify the signals involved in the adhesion and subsequent migration of lymphocytes across the endothelium (REC) and pigment epithelium (RPE) of the blood-retina barrier we have studied the effects of monoclonal antibodies (mAb) to rat adhesion/accessory molecules on the binding of normal and concanavalin A (Con A)-activated rat spleen lymphocytes to cultured unstimulated and interferon-gamma (IFN-gamma)-stimulated RPE and REC. Forty to 48% of unactivated T cells were found to bind to normal REC or RPE by leucocyte function-associated antigen-1/intercellular adhesion molecule-1 (LFA-1/ICAM-1)-independent mechanisms, despite constitutive expression of ICAM-1 by the RPE cells and LFA-1 by the T cells. Con A-activated lymphocytes showed an enhanced adhesion to both RPE and REC. However, IFN-gamma-stimulated RPE and REC did not demonstrate a significant increase in adhesiveness for normal lymphocytes highlighting the importance of lymphocyte integrin activation from low-affinity to high-affinity state. Activated lymphocyte adhesion to unstimulated RPE and REC was significantly blocked by LFA-1 mAb (35%, P < 0.0001) and ICAM-1 mAb (20%, P < 0.001). Inhibition of adhesion by antibody to CD2 was not significant. Both ICAM-1 and LFA-1 mAb also significantly (P < 0.05) blocked antigen presentation following retinal extract stimulation of lymphocytes from immunized rats in proliferation assay. These data suggest that the ICAM-1/LFA-1 system is important in lymphocyte trafficking into the eye only after lymphocyte activation." @default.
• W256976557 created "2016-06-24" @default.
• W256976557 creator A5002210515 @default.
• W256976557 creator A5041485823 @default.
• W256976557 creator A5077433762 @default.
• W256976557 date "1994-09-01" @default.
• W256976557 modified "2023-10-18" @default.
• W256976557 title "ICAM-1/LFA-1 interactions in T-lymphocyte activation and adhesion to cells of the blood-retina barrier in the rat." @default.
• W256976557 cites W1469469324 @default.
• W256976557 cites W1521359488 @default.
• W256976557 cites W1537163363 @default.
• W256976557 cites W1578496994 @default.
• W256976557 cites W1966842062 @default.
• W256976557 cites W2000467938 @default.
• W256976557 cites W2013381560 @default.
• W256976557 cites W2027342157 @default.
• W256976557 cites W2028146382 @default.
• W256976557 cites W2028418732 @default.
• W256976557 cites W2031464548 @default.
• W256976557 cites W2054321435 @default.
• W256976557 cites W2065270456 @default.
• W256976557 cites W2077634410 @default.
• W256976557 cites W2082277403 @default.
• W256976557 cites W2082655991 @default.
• W256976557 cites W2084093106 @default.
• W256976557 cites W2115536654 @default.
• W256976557 cites W2138239795 @default.
• W256976557 cites W2157279574 @default.
• W256976557 cites W2172383460 @default.
• W256976557 cites W2179076164 @default.
• W256976557 cites W2473665762 @default.
• W256976557 cites W321326367 @default.
• W256976557 cites W79749221 @default.
• W256976557 cites W8775758 @default.
• W256976557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1415018" @default.
• W256976557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7821966" @default.
• W256976557 hasPublicationYear "1994" @default.
• W256976557 type Work @default.
• W256976557 sameAs 256976557 @default.
• W256976557 citedByCount "17" @default.
• W256976557 countsByYear W2569765572012 @default.
• W256976557 countsByYear W2569765572013 @default.
• W256976557 countsByYear W2569765572015 @default.
• W256976557 countsByYear W2569765572019 @default.
• W256976557 countsByYear W2569765572021 @default.
• W256976557 countsByYear W2569765572022 @default.
• W256976557 crossrefType "journal-article" @default.
• W256976557 hasAuthorship W256976557A5002210515 @default.
• W256976557 hasAuthorship W256976557A5041485823 @default.
• W256976557 hasAuthorship W256976557A5077433762 @default.
• W256976557 hasConcept C147483822 @default.
• W256976557 hasConcept C153911025 @default.
• W256976557 hasConcept C159654299 @default.
• W256976557 hasConcept C16224149 @default.
• W256976557 hasConcept C178790620 @default.
• W256976557 hasConcept C185592680 @default.
• W256976557 hasConcept C185946421 @default.
• W256976557 hasConcept C203014093 @default.
• W256976557 hasConcept C2777761686 @default.
• W256976557 hasConcept C2778593620 @default.
• W256976557 hasConcept C2909375385 @default.
• W256976557 hasConcept C2992881475 @default.
• W256976557 hasConcept C542903549 @default.
• W256976557 hasConcept C84416704 @default.
• W256976557 hasConcept C86803240 @default.
• W256976557 hasConcept C95444343 @default.
• W256976557 hasConceptScore W256976557C147483822 @default.
• W256976557 hasConceptScore W256976557C153911025 @default.
• W256976557 hasConceptScore W256976557C159654299 @default.
• W256976557 hasConceptScore W256976557C16224149 @default.
• W256976557 hasConceptScore W256976557C178790620 @default.
• W256976557 hasConceptScore W256976557C185592680 @default.
• W256976557 hasConceptScore W256976557C185946421 @default.
• W256976557 hasConceptScore W256976557C203014093 @default.
• W256976557 hasConceptScore W256976557C2777761686 @default.
• W256976557 hasConceptScore W256976557C2778593620 @default.
• W256976557 hasConceptScore W256976557C2909375385 @default.
• W256976557 hasConceptScore W256976557C2992881475 @default.
• W256976557 hasConceptScore W256976557C542903549 @default.
• W256976557 hasConceptScore W256976557C84416704 @default.
• W256976557 hasConceptScore W256976557C86803240 @default.
• W256976557 hasConceptScore W256976557C95444343 @default.
• W256976557 hasIssue "1" @default.
• W256976557 hasLocation W2569765571 @default.
• W256976557 hasOpenAccess W256976557 @default.
• W256976557 hasPrimaryLocation W2569765571 @default.
• W256976557 hasRelatedWork W1719115680 @default.
• W256976557 hasRelatedWork W1986763742 @default.
• W256976557 hasRelatedWork W1986857320 @default.
• W256976557 hasRelatedWork W2018076492 @default.
• W256976557 hasRelatedWork W2046081503 @default.
• W256976557 hasRelatedWork W2090622131 @default.
• W256976557 hasRelatedWork W2143125251 @default.
• W256976557 hasRelatedWork W2367612296 @default.
• W256976557 hasRelatedWork W256976557 @default.
• W256976557 hasRelatedWork W3149908830 @default.
• W256976557 hasVolume "83" @default.
• W256976557 isParatext "false" @default.

• next