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- W2569773642 abstract "Background Few studies have assessed the role of lung diffusing capacity (DLCO%) in bronchiectasis. We sought to examine the relationship between DLCO% and clinical and radiological variables in a well-defined population of bronchiectasis patients to determine its potential prognostic significance and compare with FEV1%. Methods Of 312 consecutive bronchiectasis patients attending our institution over a 3-year period, 204 patients were suitable for study inclusion. Exclusion criteria consisted of patients with cystic fibrosis or traction bronchiectasis, patients with missing data and patients with absent radiological evidence of bronchiectasis on independent expert thoracic radiologist review. Univariate analyses was performed using Pearson’s correlation. Backwards stepwise logistic regression analysis was subsequently performed to determine independent associations of DLCO% and FEV1%. Results DLCO% strongly correlated with all measured lung function parameters FEV1%, FVC%, FEF 25–75% and FEV1/FVC ratio (all p Conclusion DLCO% predicts radiological disease, disease severity and mortality in bronchiectasis, independently of aetiology, and may identify patients with advanced disease who could benefit from intensive management." @default.
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- W2569773642 date "2016-11-15" @default.
- W2569773642 modified "2023-09-25" @default.
- W2569773642 title "P267 Dlco predicts disease severity and mortality in bronchiectasis" @default.
- W2569773642 doi "https://doi.org/10.1136/thoraxjnl-2016-209333.410" @default.
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