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- W2569889726 abstract "Mouse polyomavirus (MuPyV) causes a smoldering persistent infection in immunocompetent mice. To lower MuPyV infection in acutely and persistently infected mice, and study the impact of a temporal reduction in viral loads on the memory CD8 T cell response, we created a recombinant MuPyV in which a loxP sequence was inserted into the A2 strain genome upstream of the early promoter and another loxP sequence was inserted in cis into the intron shared by all three T antigens. Using mice transgenic for tamoxifen-inducible Cre recombinase, we demonstrated that reduction in MuPyV load during persistent infection was associated with differentiation of virus-specific CD8 T cells having a superior recall response. Evidence presented here supports the concept that reduction in viral load during persistent infection can promote differentiation of protective virus-specific memory CD8 T cells in patients at risk for diseases caused by human polyomaviruses." @default.
- W2569889726 created "2017-01-13" @default.
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- W2569889726 date "2017-02-01" @default.
- W2569889726 modified "2023-09-26" @default.
- W2569889726 title "Reducing persistent polyomavirus infection increases functionality of virus-specific memory CD8 T cells" @default.
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- W2569889726 doi "https://doi.org/10.1016/j.virol.2016.12.028" @default.
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