Matches in SemOpenAlex for { <https://semopenalex.org/work/W2570059429> ?p ?o ?g. }
- W2570059429 endingPage "e2528" @default.
- W2570059429 startingPage "e2528" @default.
- W2570059429 abstract "Cell death occurs in all eukaryotes, but it is still not known whether some core steps of the cell death process are conserved. We investigated this using the protist Dictyostelium. The dissection of events in Dictyostelium vacuolar developmental cell death was facilitated by the sequential requirement for two distinct exogenous signals. An initial exogenous signal (starvation and cAMP) recruited some cells into clumps. Only within these clumps did subsequent cell death events take place. Contrary to our expectations, already this initial signal provoked nucleolar disorganization and irreversible inhibition of rRNA and DNA synthesis, reflecting marked cell dysfunction. The initial signal also primed clumped cells to respond to a second exogenous signal (differentiation-inducing factor-1 or c-di-GMP), which led to vacuolization and synthesis of cellulose encasings. Thus, the latter prominent hallmarks of developmental cell death were induced separately from initial cell dysfunction. We propose that (1) in Dictyostelium vacuolization and cellulose encasings are late, organism-specific, hallmarks, and (2) on the basis of our observations in this protist and of similar previous observations in some cases of mammalian cell death, early inhibition of rRNA synthesis and nucleolar disorganization may be conserved in some eukaryotes to usher in developmental cell death." @default.
- W2570059429 created "2017-01-13" @default.
- W2570059429 creator A5009562986 @default.
- W2570059429 creator A5032849126 @default.
- W2570059429 creator A5067384731 @default.
- W2570059429 creator A5079533029 @default.
- W2570059429 creator A5084399154 @default.
- W2570059429 date "2017-01-05" @default.
- W2570059429 modified "2023-10-18" @default.
- W2570059429 title "Early nucleolar disorganization in Dictyostelium cell death" @default.
- W2570059429 cites W1515258209 @default.
- W2570059429 cites W152874300 @default.
- W2570059429 cites W1537797514 @default.
- W2570059429 cites W1681431349 @default.
- W2570059429 cites W174558702 @default.
- W2570059429 cites W1836259792 @default.
- W2570059429 cites W1842077267 @default.
- W2570059429 cites W1862346079 @default.
- W2570059429 cites W1885853845 @default.
- W2570059429 cites W1892554314 @default.
- W2570059429 cites W1920284083 @default.
- W2570059429 cites W1974473949 @default.
- W2570059429 cites W1982447331 @default.
- W2570059429 cites W1990523844 @default.
- W2570059429 cites W1996637141 @default.
- W2570059429 cites W1998313923 @default.
- W2570059429 cites W1999440327 @default.
- W2570059429 cites W1999962568 @default.
- W2570059429 cites W2002373110 @default.
- W2570059429 cites W2002788522 @default.
- W2570059429 cites W2024082466 @default.
- W2570059429 cites W2026152653 @default.
- W2570059429 cites W2029824179 @default.
- W2570059429 cites W2035384099 @default.
- W2570059429 cites W2039516373 @default.
- W2570059429 cites W2040483206 @default.
- W2570059429 cites W2040546382 @default.
- W2570059429 cites W2040675788 @default.
- W2570059429 cites W2043013395 @default.
- W2570059429 cites W2045308252 @default.
- W2570059429 cites W2046091459 @default.
- W2570059429 cites W2046576681 @default.
- W2570059429 cites W2052273361 @default.
- W2570059429 cites W2057135485 @default.
- W2570059429 cites W2062757045 @default.
- W2570059429 cites W2063859600 @default.
- W2570059429 cites W2068695850 @default.
- W2570059429 cites W2070204274 @default.
- W2570059429 cites W2074076572 @default.
- W2570059429 cites W2074840129 @default.
- W2570059429 cites W2082840125 @default.
- W2570059429 cites W2085911580 @default.
- W2570059429 cites W2086497778 @default.
- W2570059429 cites W2089128372 @default.
- W2570059429 cites W2092869829 @default.
- W2570059429 cites W2096345860 @default.
- W2570059429 cites W2100893053 @default.
- W2570059429 cites W2103272211 @default.
- W2570059429 cites W2121614812 @default.
- W2570059429 cites W2126556619 @default.
- W2570059429 cites W2129104457 @default.
- W2570059429 cites W2132370546 @default.
- W2570059429 cites W2133468902 @default.
- W2570059429 cites W2134608649 @default.
- W2570059429 cites W2136817553 @default.
- W2570059429 cites W2146609854 @default.
- W2570059429 cites W2152606927 @default.
- W2570059429 cites W2154977216 @default.
- W2570059429 cites W2155352156 @default.
- W2570059429 cites W2155366353 @default.
- W2570059429 cites W2159316973 @default.
- W2570059429 cites W2166613767 @default.
- W2570059429 cites W2193769732 @default.
- W2570059429 cites W2208555666 @default.
- W2570059429 cites W2274487702 @default.
- W2570059429 cites W2323899852 @default.
- W2570059429 cites W2493253456 @default.
- W2570059429 cites W2742272146 @default.
- W2570059429 cites W2798259643 @default.
- W2570059429 cites W4231439871 @default.
- W2570059429 cites W4248321796 @default.
- W2570059429 cites W4255830188 @default.
- W2570059429 doi "https://doi.org/10.1038/cddis.2016.444" @default.
- W2570059429 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5386361" @default.
- W2570059429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28055008" @default.
- W2570059429 hasPublicationYear "2017" @default.
- W2570059429 type Work @default.
- W2570059429 sameAs 2570059429 @default.
- W2570059429 citedByCount "7" @default.
- W2570059429 countsByYear W25700594292017 @default.
- W2570059429 countsByYear W25700594292018 @default.
- W2570059429 countsByYear W25700594292019 @default.
- W2570059429 countsByYear W25700594292020 @default.
- W2570059429 crossrefType "journal-article" @default.
- W2570059429 hasAuthorship W2570059429A5009562986 @default.
- W2570059429 hasAuthorship W2570059429A5032849126 @default.
- W2570059429 hasAuthorship W2570059429A5067384731 @default.
- W2570059429 hasAuthorship W2570059429A5079533029 @default.