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- W2570126051 abstract "Introduction and objectives Idiopathic Pulmonary Fibrosis (IPF) is strongly associated with advanced age. Our aim is to identify if the baseline characteristics of patients aged >80 who are excluded from pharmaceutical trials differ compared to patients aged Methods Consecutively diagnosed IPF patients ≥80 (n = 61) and 1 , FVC, DLco and Kco) were extracted from medical records. All cases were discussed by an ILD multi-disciplinary panel for the purpose of assigning a consensus diagnosis. Results The baseline characteristics of both study groups are summarised in Table 1. Patients were also grouped by smoking status; the smoking history of 10 patients in the ≥80 and 3 patients in the We divided both groups to smokers and non-smokers. FEV 1 and FVC did not differ between non-smokers from both study groups whereas were both significantly lower in the smokers aged 80 years (74,44 ± 18,24 versus 86,34 ± 12,67 p = 0.0005 for FEV 1 and 72,96 ± 20,77 versus 88,34 ± 13,68 p = 0.0001 for FVC). DLco and Kco did not differ between smokers and non-smokers. Conclusion Patients with IPF aged ≥80 years present with higher spirometric values than those 80 compared to younger smokers could be due to the concomitant presence of radiologically evident emphysema. This finding has clinical implications with respect to eligibility for NICE-approved anti-fibrotic treatment. Analysis of the extent of emphysema in these patients and further studies of a higher number of patients is underway." @default.
- W2570126051 created "2017-01-13" @default.
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- W2570126051 date "2016-11-15" @default.
- W2570126051 modified "2023-09-26" @default.
- W2570126051 title "P273 Baseline characteristics of patients with idiopathic pulmonary fibrosis aged over 80 years old" @default.
- W2570126051 doi "https://doi.org/10.1136/thoraxjnl-2016-209333.416" @default.
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