FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2570135590> ?p ?o ?g. }

• W2570135590 endingPage "30" @default.
• W2570135590 startingPage "22" @default.
• W2570135590 abstract "Interactions between the polyamine spermine and nucleic acids drive important cellular processes. Spermine condenses DNA and some RNAs, such as poly(rA):poly(rU). A large fraction of the spermine present in cells is bound to RNA but apparently does not condense it. Here, we study the effect of spermine binding to short duplex RNA and DNA, and compare our findings with predictions of molecular-dynamics simulations. When small numbers of spermine are introduced, RNA with a designed sequence containing a mixture of 14 GC pairs and 11 AU pairs resists condensation relative to DNA of an equivalent sequence or to 25 bp poly(rA):poly(rU) RNA. A comparison of wide-angle x-ray scattering profiles with simulation results suggests that spermine is sequestered deep within the major groove of mixed-sequence RNA. This prevents condensation by limiting opportunities to bridge to other molecules and stabilizes the RNA by locking it into a particular conformation. In contrast, for DNA, simulations suggest that spermine binds externally to the duplex, offering opportunities for intermolecular interaction. The goal of this study is to explain how RNA can remain soluble and available for interaction with other molecules in the cell despite the presence of spermine at concentrations high enough to precipitate DNA." @default.
• W2570135590 created "2017-01-13" @default.
• W2570135590 creator A5011446168 @default.
• W2570135590 creator A5016954340 @default.
• W2570135590 creator A5022075325 @default.
• W2570135590 creator A5048825128 @default.
• W2570135590 creator A5065734267 @default.
• W2570135590 creator A5076984889 @default.
• W2570135590 date "2017-01-01" @default.
• W2570135590 modified "2023-10-10" @default.
• W2570135590 title "Spermine Condenses DNA, but Not RNA Duplexes" @default.
• W2570135590 cites W131896979 @default.
• W2570135590 cites W1498399113 @default.
• W2570135590 cites W1544991224 @default.
• W2570135590 cites W1564441910 @default.
• W2570135590 cites W1969469290 @default.
• W2570135590 cites W1970429992 @default.
• W2570135590 cites W1972570207 @default.
• W2570135590 cites W1974781990 @default.
• W2570135590 cites W1977140054 @default.
• W2570135590 cites W1977393572 @default.
• W2570135590 cites W1978438294 @default.
• W2570135590 cites W1981225934 @default.
• W2570135590 cites W1981365891 @default.
• W2570135590 cites W1982117833 @default.
• W2570135590 cites W1982584848 @default.
• W2570135590 cites W1983176420 @default.
• W2570135590 cites W1991687435 @default.
• W2570135590 cites W2003296422 @default.
• W2570135590 cites W2009658850 @default.
• W2570135590 cites W2020002410 @default.
• W2570135590 cites W2020247801 @default.
• W2570135590 cites W2023976091 @default.
• W2570135590 cites W2026062562 @default.
• W2570135590 cites W2026905039 @default.
• W2570135590 cites W2029485175 @default.
• W2570135590 cites W2037773996 @default.
• W2570135590 cites W2045570700 @default.
• W2570135590 cites W2050560798 @default.
• W2570135590 cites W2051476868 @default.
• W2570135590 cites W2052333294 @default.
• W2570135590 cites W2056315229 @default.
• W2570135590 cites W2059951700 @default.
• W2570135590 cites W2066690664 @default.
• W2570135590 cites W2067644748 @default.
• W2570135590 cites W2070271523 @default.
• W2570135590 cites W2072565613 @default.
• W2570135590 cites W2084558621 @default.
• W2570135590 cites W2090353848 @default.
• W2570135590 cites W2091362477 @default.
• W2570135590 cites W2091765441 @default.
• W2570135590 cites W2095633058 @default.
• W2570135590 cites W2099921426 @default.
• W2570135590 cites W2103325328 @default.
• W2570135590 cites W2116609429 @default.
• W2570135590 cites W2118233996 @default.
• W2570135590 cites W2136729627 @default.
• W2570135590 cites W2143697213 @default.
• W2570135590 cites W2163451322 @default.
• W2570135590 cites W2170083300 @default.
• W2570135590 cites W2240209487 @default.
• W2570135590 cites W2275658165 @default.
• W2570135590 cites W2310029472 @default.
• W2570135590 cites W2316392160 @default.
• W2570135590 cites W2437067295 @default.
• W2570135590 cites W2962951846 @default.
• W2570135590 cites W3099866331 @default.
• W2570135590 cites W3100537091 @default.
• W2570135590 cites W3101108314 @default.
• W2570135590 cites W4238270754 @default.
• W2570135590 cites W561468730 @default.
• W2570135590 doi "https://doi.org/10.1016/j.bpj.2016.11.018" @default.
• W2570135590 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5232352" @default.
• W2570135590 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28076812" @default.
• W2570135590 hasPublicationYear "2017" @default.
• W2570135590 type Work @default.
• W2570135590 sameAs 2570135590 @default.
• W2570135590 citedByCount "46" @default.
• W2570135590 countsByYear W25701355902017 @default.
• W2570135590 countsByYear W25701355902018 @default.
• W2570135590 countsByYear W25701355902019 @default.
• W2570135590 countsByYear W25701355902020 @default.
• W2570135590 countsByYear W25701355902021 @default.
• W2570135590 countsByYear W25701355902022 @default.
• W2570135590 countsByYear W25701355902023 @default.
• W2570135590 crossrefType "journal-article" @default.
• W2570135590 hasAuthorship W2570135590A5011446168 @default.
• W2570135590 hasAuthorship W2570135590A5016954340 @default.
• W2570135590 hasAuthorship W2570135590A5022075325 @default.
• W2570135590 hasAuthorship W2570135590A5048825128 @default.
• W2570135590 hasAuthorship W2570135590A5065734267 @default.
• W2570135590 hasAuthorship W2570135590A5076984889 @default.
• W2570135590 hasBestOaLocation W25701355901 @default.
• W2570135590 hasConcept C104317684 @default.
• W2570135590 hasConcept C115028873 @default.
• W2570135590 hasConcept C12554922 @default.
• W2570135590 hasConcept C126142528 @default.
• W2570135590 hasConcept C181199279 @default.

• next