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- W2570135650 abstract "Abstract Muscle contraction is driven by cyclic association and dissociation of myosin head of the thick filament with thin actin filament coupled with ATP binding and hydrolysis by myosin. However, because of the absence of actomyosin rigour structure at high resolution, it still remains unclear how the strong binding of myosin to actin filament triggers the release of hydrolysis products and how ATP binding causes their dissociation. Here we report the structure of mammalian skeletal muscle actomyosin rigour complex at 5.2 Å resolution by electron cryomicroscopy. Comparison with the structures of myosin in various states shows a distinctly large conformational change, providing insights into the ATPase-coupled reaction cycle of actomyosin. Based on our observations, we hypothesize that asymmetric binding along the actin filament could function as a Brownian ratchet by favouring directionally biased thermal motions of myosin and actin." @default.
- W2570135650 created "2017-01-13" @default.
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- W2570135650 date "2017-01-09" @default.
- W2570135650 modified "2023-10-13" @default.
- W2570135650 title "Structure of actomyosin rigour complex at 5.2 Å resolution and insights into the ATPase cycle mechanism" @default.
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- W2570135650 doi "https://doi.org/10.1038/ncomms13969" @default.
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