Matches in SemOpenAlex for { <https://semopenalex.org/work/W2570185708> ?p ?o ?g. }
- W2570185708 abstract "Recent studies suggest a role for T lymphocytes in hypertension. However, whether T cells contribute to renal sodium retention and salt-sensitive hypertension is unknown. Here we demonstrate that T cells infiltrate into the kidney of salt-sensitive hypertensive animals. In particular, CD8+ T cells directly contact the distal convoluted tubule (DCT) in the kidneys of DOCA-salt mice and CD8+ T cell-injected mice, leading to up-regulation of the Na-Cl co-transporter NCC, p-NCC and the development of salt-sensitive hypertension. Co-culture with CD8+ T cells upregulates NCC in mouse DCT cells via ROS-induced activation of Src kinase, up-regulation of the K+ channel Kir4.1, and stimulation of the Cl- channel ClC-K. The last event increases chloride efflux, leading to compensatory chloride influx via NCC activation at the cost of increasing sodium retention. Collectively, these findings provide a mechanism for adaptive immunity involvement in the kidney defect in sodium handling and the pathogenesis of salt-sensitive hypertension." @default.
- W2570185708 created "2017-01-13" @default.
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- W2570185708 date "2017-01-09" @default.
- W2570185708 modified "2023-10-17" @default.
- W2570185708 title "CD8+ T cells stimulate Na-Cl co-transporter NCC in distal convoluted tubules leading to salt-sensitive hypertension" @default.
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- W2570185708 doi "https://doi.org/10.1038/ncomms14037" @default.
- W2570185708 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5227995" @default.
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