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- W2570229825 endingPage "17346" @default.
- W2570229825 startingPage "17328" @default.
- W2570229825 abstract "As one of the most commonly diagnosed cancers worldwide, colorectal adenocarcinoma often occurs sporadically in individuals aged 50 or above and there is an increase among younger patients under 50. Routine screenings are recommended for this age group to improve early detection. The multifactorial etiology of colorectal cancer consists of both genetic and epigenetic factors. Recently, studies have shown that the development and progression of colorectal cancer can be attributed to aberrant expression of microRNA. Reactive oxygen species (ROS) that play a key role in cancer cell survival, can also lead to carcinogenesis and cancer exacerbations. Given the rapid accumulating knowledge in the field, an updated review regarding microRNA and ROS in colorectal cancer is necessary. An extensive literature search has been conducted in PubMed/Medline databases to review the roles of microRNAs and ROS in colorectal cancer. Unique microRNA expression in tumor tissue, peripheral blood, and fecal samples from patients with colorectal cancer is outlined. Therapeutic approaches focusing on microRNA and ROS in colorectal cancer treatment is also delineated. This review aims to summarize the newest knowledge on the pathogenesis of colorectal cancer in the hopes of discovering novel diagnostic biomarkers and therapeutic techniques." @default.
- W2570229825 created "2017-01-13" @default.
- W2570229825 creator A5020761274 @default.
- W2570229825 creator A5060874603 @default.
- W2570229825 creator A5073199916 @default.
- W2570229825 date "2017-01-03" @default.
- W2570229825 modified "2023-10-12" @default.
- W2570229825 title "Potential roles of microRNAs and ROS in colorectal cancer: diagnostic biomarkers and therapeutic targets" @default.
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