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- W2570267130 endingPage "88" @default.
- W2570267130 startingPage "88" @default.
- W2570267130 abstract "Liver X receptors (LXRs) have been increasingly recognized as a potential therapeutic target to treat pathological conditions ranging from vascular and metabolic diseases, neurological degeneration, to cancers that are driven by lipid metabolism. Amidst intensifying efforts to discover ligands that act through LXRs to achieve the sought-after pharmacological outcomes, several lead compounds are already being tested in clinical trials for a variety of disease interventions. While more potent and selective LXR ligands continue to emerge from screening of small molecule libraries, rational design, and empirical medicinal chemistry approaches, challenges remain in minimizing undesirable effects of LXR activation on lipid metabolism. This review provides a summary of known endogenous, naturally occurring, and synthetic ligands. The review also offers considerations from a molecular modeling perspective with which to design more specific LXRβ ligands based on the interaction energies of ligands and the important amino acid residues in the LXRβ ligand binding domain." @default.
- W2570267130 created "2017-01-13" @default.
- W2570267130 creator A5029500388 @default.
- W2570267130 creator A5031346796 @default.
- W2570267130 creator A5031538800 @default.
- W2570267130 creator A5034029143 @default.
- W2570267130 creator A5050765428 @default.
- W2570267130 creator A5078595868 @default.
- W2570267130 date "2017-01-05" @default.
- W2570267130 modified "2023-09-26" @default.
- W2570267130 title "Ligands of Therapeutic Utility for the Liver X Receptors" @default.
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