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- W2570293024 abstract "Abnormalities in dendritic spines are manifestations of several neurodevelopmental and psychiatric diseases. TAOK2 is one of the genes in the 16p11.2 locus, copy number variations of which are associated with autism and schizophrenia. Here, we show that the kinase activity of the serine/threonine kinase encoded by TAOK2 is required for spine maturation. TAOK2 depletion results in unstable dendritic protrusions, mislocalized shaft-synapses, and loss of compartmentalization of NMDA receptor-mediated calcium influx. Using chemical-genetics and mass spectrometry, we identified several TAOK2 phosphorylation targets. We show that TAOK2 directly phosphorylates the cytoskeletal GTPase Septin7, at an evolutionary conserved residue. This phosphorylation induces translocation of Septin7 to the spine, where it associates with and stabilizes the scaffolding protein PSD95, promoting dendritic spine maturation. This study provides a mechanistic basis for postsynaptic stability and compartmentalization via TAOK2-Sept7 signaling, with implications toward understanding the potential role of TAOK2 in neurological deficits associated with the 16p11.2 region." @default.
- W2570293024 created "2017-01-13" @default.
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- W2570293024 date "2017-01-01" @default.
- W2570293024 modified "2023-10-12" @default.
- W2570293024 title "TAOK2 Kinase Mediates PSD95 Stability and Dendritic Spine Maturation through Septin7 Phosphorylation" @default.
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- W2570293024 cites W1969983616 @default.
- W2570293024 cites W1971321176 @default.
- W2570293024 cites W1984617454 @default.
- W2570293024 cites W1988476536 @default.
- W2570293024 cites W1989276229 @default.
- W2570293024 cites W1991660576 @default.
- W2570293024 cites W1993020997 @default.
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- W2570293024 cites W2001528712 @default.
- W2570293024 cites W2003879033 @default.
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- W2570293024 cites W2006018605 @default.
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- W2570293024 doi "https://doi.org/10.1016/j.neuron.2016.12.006" @default.
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