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• W2570296070 startingPage "971" @default.
• W2570296070 abstract "Summary Human induced pluripotent stem cells (hi PSC s) are being considered for use in understanding haematopoietic disorders and as a potential source of in vitro manufactured red cells. Here, we show that hi PSC s are able to recapitulate various stages of developmental erythropoiesis. We show that primitive erythroblasts arise first, express CD 31 + with CD 235a + , embryonic globins and red cell markers, but fail to express the hallmark red cell transcripts of adult erythropoiesis. When hi PSC ‐derived CD 45 + CD 235a − haematopoietic progenitors are isolated on day 12 and further differentiated on OP 9 stroma, they selectively express CD 36 + and CD 235a + , adult erythroid transcripts for transcription factors (e.g., BCL 11A, KLF 1 ) and fetal/adult globins ( HBG 1/2, HBB ). Importantly, hi PSC ‐ and cord‐derived CD 36 + CD 235a + erythroblasts show a striking homology by transcriptome array profiling (only 306 transcripts with a 2Log fold change >1·5‐ or 2·8‐fold). Phenotypic and transcriptome profiling of CD 45 + CD 117 + CD 235a + pro‐erythroblasts and terminally differentiated erythroblasts is also provided, including evidence of a HbF (fetal) to HbA (adult) haemoglobin switch and enucleation, that mirrors their definitive erythroblast cord‐derived counterparts. These findings provide a molecular roadmap of developmental erythropoiesis from hi PSC sources at several critical stages, but also helps to inform on their use for clinical applications and modelling human haematopoietic disease." @default.
• W2570296070 created "2017-01-13" @default.
• W2570296070 creator A5002450989 @default.
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• W2570296070 date "2017-01-06" @default.
• W2570296070 modified "2023-10-04" @default.
• W2570296070 title "A molecular roadmap of definitive erythropoiesis from human induced pluripotent stem cells" @default.
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• W2570296070 doi "https://doi.org/10.1111/bjh.14491" @default.
• W2570296070 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28060419" @default.
• W2570296070 hasPublicationYear "2017" @default.
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