Matches in SemOpenAlex for { <https://semopenalex.org/work/W2570344018> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2570344018 abstract "Abstract Abstract 3178 Background: HMG CoA reductase inhibitors (statins) were recently reported to reduce the rate of venous thromboembolism (VTE) in healthy people. Statins reduce levels of inflammation biomarkers, however the mechanism for a reduction in VTE risk is unknown. We studied cross-sectional associations of statin use with hemostatic factors related to venous thrombosis risk in a large cohort of healthy people. Methods: Cross-sectional analyses were performed in the Multi-Ethnic Study of Atherosclerosis (MESA), a cohort study of 6814 healthy men and women age 45–84, free of clinical cardiovascular disease at baseline; 1001 were using statins. Twenty three warfarin users were excluded. Age, race, and sex-adjusted mean hemostatic factor levels were compared between statin users and nonusers, and multivariable linear regression models were used to assess associations of statin use with hemostasis factors, adjusted for age, race/ethnicity, education, income, hormone replacement therapy (in women) and major cardiovascular risk factors. Results: The table shows that those using statins had significantly lower levels of D-dimer, C-reactive protein and factor VIII than non-users. Homocysteine and von Willebrand factor did not differ by statin use. Specific adjustment for LDL and triglycerides did not attenuate the observed differences in these factors by statin use. Conclusions: Findings of lower D-dimer, factor VIII and C-reactive protein levels with statin use suggest mechanisms whereby statins might lower VTE risk. These associations were not explained by lipid levels on treatment. A prospective study linking these biochemical differences to VTE outcomes is warranted. Disclosures: No relevant conflicts of interest to declare." @default.
- W2570344018 created "2017-01-13" @default.
- W2570344018 creator A5012145772 @default.
- W2570344018 creator A5019582883 @default.
- W2570344018 creator A5023858070 @default.
- W2570344018 creator A5025347701 @default.
- W2570344018 creator A5036010255 @default.
- W2570344018 creator A5036551563 @default.
- W2570344018 creator A5075061959 @default.
- W2570344018 creator A5088938428 @default.
- W2570344018 creator A5091739087 @default.
- W2570344018 date "2010-11-19" @default.
- W2570344018 modified "2023-10-01" @default.
- W2570344018 title "Statin Therapy and Levels of Thrombosis Risk Factors In a Healthy Population: the Multi-Ethnic Study of Atherosclerosis" @default.
- W2570344018 doi "https://doi.org/10.1182/blood.v116.21.3178.3178" @default.
- W2570344018 hasPublicationYear "2010" @default.
- W2570344018 type Work @default.
- W2570344018 sameAs 2570344018 @default.
- W2570344018 citedByCount "0" @default.
- W2570344018 crossrefType "journal-article" @default.
- W2570344018 hasAuthorship W2570344018A5012145772 @default.
- W2570344018 hasAuthorship W2570344018A5019582883 @default.
- W2570344018 hasAuthorship W2570344018A5023858070 @default.
- W2570344018 hasAuthorship W2570344018A5025347701 @default.
- W2570344018 hasAuthorship W2570344018A5036010255 @default.
- W2570344018 hasAuthorship W2570344018A5036551563 @default.
- W2570344018 hasAuthorship W2570344018A5075061959 @default.
- W2570344018 hasAuthorship W2570344018A5088938428 @default.
- W2570344018 hasAuthorship W2570344018A5091739087 @default.
- W2570344018 hasConcept C126322002 @default.
- W2570344018 hasConcept C1862650 @default.
- W2570344018 hasConcept C188816634 @default.
- W2570344018 hasConcept C2776839432 @default.
- W2570344018 hasConcept C2780868729 @default.
- W2570344018 hasConcept C2908647359 @default.
- W2570344018 hasConcept C50440223 @default.
- W2570344018 hasConcept C71924100 @default.
- W2570344018 hasConcept C72563966 @default.
- W2570344018 hasConcept C99454951 @default.
- W2570344018 hasConceptScore W2570344018C126322002 @default.
- W2570344018 hasConceptScore W2570344018C1862650 @default.
- W2570344018 hasConceptScore W2570344018C188816634 @default.
- W2570344018 hasConceptScore W2570344018C2776839432 @default.
- W2570344018 hasConceptScore W2570344018C2780868729 @default.
- W2570344018 hasConceptScore W2570344018C2908647359 @default.
- W2570344018 hasConceptScore W2570344018C50440223 @default.
- W2570344018 hasConceptScore W2570344018C71924100 @default.
- W2570344018 hasConceptScore W2570344018C72563966 @default.
- W2570344018 hasConceptScore W2570344018C99454951 @default.
- W2570344018 hasLocation W25703440181 @default.
- W2570344018 hasOpenAccess W2570344018 @default.
- W2570344018 hasPrimaryLocation W25703440181 @default.
- W2570344018 hasRelatedWork W1967780514 @default.
- W2570344018 hasRelatedWork W1975096570 @default.
- W2570344018 hasRelatedWork W2048590478 @default.
- W2570344018 hasRelatedWork W2071768463 @default.
- W2570344018 hasRelatedWork W2073289400 @default.
- W2570344018 hasRelatedWork W2401230985 @default.
- W2570344018 hasRelatedWork W2551697949 @default.
- W2570344018 hasRelatedWork W2573429490 @default.
- W2570344018 hasRelatedWork W2583780110 @default.
- W2570344018 hasRelatedWork W2738683652 @default.
- W2570344018 hasRelatedWork W2792188134 @default.
- W2570344018 hasRelatedWork W2802791657 @default.
- W2570344018 hasRelatedWork W2883633947 @default.
- W2570344018 hasRelatedWork W2884135367 @default.
- W2570344018 hasRelatedWork W2917522797 @default.
- W2570344018 hasRelatedWork W3108461579 @default.
- W2570344018 hasRelatedWork W3137131941 @default.
- W2570344018 hasRelatedWork W3139884448 @default.
- W2570344018 hasRelatedWork W3150089610 @default.
- W2570344018 hasRelatedWork W3208235556 @default.
- W2570344018 isParatext "false" @default.
- W2570344018 isRetracted "false" @default.
- W2570344018 magId "2570344018" @default.
- W2570344018 workType "article" @default.