Matches in SemOpenAlex for { <https://semopenalex.org/work/W2570371570> ?p ?o ?g. }
- W2570371570 endingPage "e0169044" @default.
- W2570371570 startingPage "e0169044" @default.
- W2570371570 abstract "Dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) are richly innervated by GABAergic neurons. The postsynaptic effects of GABA on SNc DA neurons are mediated by a mixture of GABAA and GABAB receptors. Although activation of GABAA receptors inhibits spike generation, the consequences of GABAB receptor activation are less well characterized. To help fill this gap, perforated patch recordings were made from young adult mouse SNc DA neurons. Sustained stimulation of GABAB receptors hyperpolarized SNc DA neurons, as previously described. However, transient stimulation of GABAB receptors by optical uncaging of GABA did not; rather, it reduced the opening of small-conductance, calcium-activated K+ (SK) channels and increased the irregularity of spiking. This modulation was attributable to inhibition of adenylyl cyclase and protein kinase A. Thus, because suppression of SK channel activity increases the probability of burst spiking, transient co-activation of GABAA and GABAB receptors could promote a pause-burst pattern of spiking." @default.
- W2570371570 created "2017-01-13" @default.
- W2570371570 creator A5022357653 @default.
- W2570371570 creator A5033742239 @default.
- W2570371570 creator A5033880175 @default.
- W2570371570 creator A5039083540 @default.
- W2570371570 creator A5052825834 @default.
- W2570371570 creator A5090513279 @default.
- W2570371570 creator A5090775384 @default.
- W2570371570 date "2016-12-30" @default.
- W2570371570 modified "2023-09-27" @default.
- W2570371570 title "Transient Activation of GABAB Receptors Suppresses SK Channel Currents in Substantia Nigra Pars Compacta Dopaminergic Neurons" @default.
- W2570371570 cites W1510439895 @default.
- W2570371570 cites W1532003108 @default.
- W2570371570 cites W1540330207 @default.
- W2570371570 cites W1542020233 @default.
- W2570371570 cites W1590345531 @default.
- W2570371570 cites W1604214492 @default.
- W2570371570 cites W1607380607 @default.
- W2570371570 cites W1764026126 @default.
- W2570371570 cites W1823302046 @default.
- W2570371570 cites W1967622946 @default.
- W2570371570 cites W1977703065 @default.
- W2570371570 cites W1978702556 @default.
- W2570371570 cites W1978731562 @default.
- W2570371570 cites W1993369233 @default.
- W2570371570 cites W1995179004 @default.
- W2570371570 cites W1997550735 @default.
- W2570371570 cites W2000617982 @default.
- W2570371570 cites W2001073214 @default.
- W2570371570 cites W2001930072 @default.
- W2570371570 cites W2006200262 @default.
- W2570371570 cites W2007281961 @default.
- W2570371570 cites W2009000152 @default.
- W2570371570 cites W2013056417 @default.
- W2570371570 cites W2015440166 @default.
- W2570371570 cites W2017120126 @default.
- W2570371570 cites W2019402390 @default.
- W2570371570 cites W2020455022 @default.
- W2570371570 cites W2027327558 @default.
- W2570371570 cites W2027899918 @default.
- W2570371570 cites W2028662903 @default.
- W2570371570 cites W2033608099 @default.
- W2570371570 cites W2033863429 @default.
- W2570371570 cites W2047941069 @default.
- W2570371570 cites W2048941040 @default.
- W2570371570 cites W2052480831 @default.
- W2570371570 cites W2055918680 @default.
- W2570371570 cites W2060052647 @default.
- W2570371570 cites W2060915664 @default.
- W2570371570 cites W2060931989 @default.
- W2570371570 cites W2061473159 @default.
- W2570371570 cites W2067678773 @default.
- W2570371570 cites W2071566065 @default.
- W2570371570 cites W2071812065 @default.
- W2570371570 cites W2071895177 @default.
- W2570371570 cites W2073036965 @default.
- W2570371570 cites W2075511856 @default.
- W2570371570 cites W2075831689 @default.
- W2570371570 cites W2076006649 @default.
- W2570371570 cites W2078395247 @default.
- W2570371570 cites W2090020119 @default.
- W2570371570 cites W2093024075 @default.
- W2570371570 cites W2096118295 @default.
- W2570371570 cites W2097805348 @default.
- W2570371570 cites W2100068597 @default.
- W2570371570 cites W2101446007 @default.
- W2570371570 cites W2110747461 @default.
- W2570371570 cites W2117726420 @default.
- W2570371570 cites W2120935292 @default.
- W2570371570 cites W2129114637 @default.
- W2570371570 cites W2134888640 @default.
- W2570371570 cites W2137215947 @default.
- W2570371570 cites W2148882983 @default.
- W2570371570 cites W2155962081 @default.
- W2570371570 cites W2156581621 @default.
- W2570371570 cites W2157658985 @default.
- W2570371570 cites W2160504671 @default.
- W2570371570 cites W2169622817 @default.
- W2570371570 cites W2171622636 @default.
- W2570371570 cites W21769058 @default.
- W2570371570 cites W2200183975 @default.
- W2570371570 cites W2395584501 @default.
- W2570371570 cites W2413295084 @default.
- W2570371570 cites W2466948651 @default.
- W2570371570 cites W4296759707 @default.
- W2570371570 doi "https://doi.org/10.1371/journal.pone.0169044" @default.
- W2570371570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5201262" @default.
- W2570371570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28036359" @default.
- W2570371570 hasPublicationYear "2016" @default.
- W2570371570 type Work @default.
- W2570371570 sameAs 2570371570 @default.
- W2570371570 citedByCount "9" @default.
- W2570371570 countsByYear W25703715702017 @default.
- W2570371570 countsByYear W25703715702019 @default.
- W2570371570 countsByYear W25703715702020 @default.
- W2570371570 countsByYear W25703715702021 @default.
- W2570371570 crossrefType "journal-article" @default.