FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2570537891> ?p ?o ?g. }

• W2570537891 abstract "Tumour metastasis, the spread of cancer cells from the original tumour site followed by growth of secondary tumours at distant organs, is the primary cause of cancer-related deaths and remains poorly understood. Here we demonstrate that inhibition of CDK4/6 blocks breast tumour metastasis in the triple-negative breast cancer model, without affecting tumour growth. Mechanistically, we identify a deubiquitinase, DUB3, as a target of CDK4/6; CDK4/6-mediated activation of DUB3 is essential to deubiquitinate and stabilize SNAIL1, a key factor promoting epithelial-mesenchymal transition and breast cancer metastasis. Overall, our study establishes the CDK4/6-DUB3 axis as an important regulatory mechanism of breast cancer metastasis and provides a rationale for potential therapeutic interventions in the treatment of breast cancer metastasis." @default.
• W2570537891 created "2017-01-13" @default.
• W2570537891 creator A5008665323 @default.
• W2570537891 creator A5009442431 @default.
• W2570537891 creator A5011840360 @default.
• W2570537891 creator A5020124376 @default.
• W2570537891 creator A5027064361 @default.
• W2570537891 creator A5028424745 @default.
• W2570537891 creator A5031722471 @default.
• W2570537891 creator A5033544737 @default.
• W2570537891 creator A5038848714 @default.
• W2570537891 creator A5049713067 @default.
• W2570537891 creator A5052128926 @default.
• W2570537891 creator A5056262012 @default.
• W2570537891 creator A5058125335 @default.
• W2570537891 creator A5058132534 @default.
• W2570537891 creator A5060970627 @default.
• W2570537891 creator A5067749727 @default.
• W2570537891 creator A5068580978 @default.
• W2570537891 creator A5069578729 @default.
• W2570537891 creator A5071672663 @default.
• W2570537891 creator A5076821651 @default.
• W2570537891 creator A5083492856 @default.
• W2570537891 creator A5091335377 @default.
• W2570537891 creator A5091587364 @default.
• W2570537891 date "2017-01-09" @default.
• W2570537891 modified "2023-10-12" @default.
• W2570537891 title "CDK4/6-dependent activation of DUB3 regulates cancer metastasis through SNAIL1" @default.
• W2570537891 cites W1906566368 @default.
• W2570537891 cites W1964081206 @default.
• W2570537891 cites W1964847767 @default.
• W2570537891 cites W1965136174 @default.
• W2570537891 cites W1972959587 @default.
• W2570537891 cites W1981752846 @default.
• W2570537891 cites W1985932544 @default.
• W2570537891 cites W1986834354 @default.
• W2570537891 cites W1991025954 @default.
• W2570537891 cites W1994242450 @default.
• W2570537891 cites W2010778165 @default.
• W2570537891 cites W2015254463 @default.
• W2570537891 cites W2017231237 @default.
• W2570537891 cites W2019919865 @default.
• W2570537891 cites W2025647419 @default.
• W2570537891 cites W2033550998 @default.
• W2570537891 cites W2038569449 @default.
• W2570537891 cites W2039090083 @default.
• W2570537891 cites W2040614639 @default.
• W2570537891 cites W2041602672 @default.
• W2570537891 cites W2042198997 @default.
• W2570537891 cites W2050481433 @default.
• W2570537891 cites W2057272791 @default.
• W2570537891 cites W2063011414 @default.
• W2570537891 cites W2068503417 @default.
• W2570537891 cites W2070058781 @default.
• W2570537891 cites W2076583198 @default.
• W2570537891 cites W2080232352 @default.
• W2570537891 cites W2081734005 @default.
• W2570537891 cites W2084136796 @default.
• W2570537891 cites W2084863590 @default.
• W2570537891 cites W2087367170 @default.
• W2570537891 cites W2092180337 @default.
• W2570537891 cites W2104268053 @default.
• W2570537891 cites W2105772211 @default.
• W2570537891 cites W2107480474 @default.
• W2570537891 cites W2109998353 @default.
• W2570537891 cites W2114906733 @default.
• W2570537891 cites W2116119295 @default.
• W2570537891 cites W2116141084 @default.
• W2570537891 cites W2121937053 @default.
• W2570537891 cites W2122483745 @default.
• W2570537891 cites W2125906593 @default.
• W2570537891 cites W2132655645 @default.
• W2570537891 cites W2137620209 @default.
• W2570537891 cites W2140551998 @default.
• W2570537891 cites W2144790402 @default.
• W2570537891 cites W2148345265 @default.
• W2570537891 cites W2150322923 @default.
• W2570537891 cites W2150416393 @default.
• W2570537891 cites W2153076514 @default.
• W2570537891 cites W2154589460 @default.
• W2570537891 cites W2157923000 @default.
• W2570537891 cites W2165200432 @default.
• W2570537891 cites W2165901622 @default.
• W2570537891 cites W2166517176 @default.
• W2570537891 cites W2166984633 @default.
• W2570537891 cites W2172083228 @default.
• W2570537891 cites W2219817965 @default.
• W2570537891 cites W4211233744 @default.
• W2570537891 doi "https://doi.org/10.1038/ncomms13923" @default.
• W2570537891 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5228031" @default.
• W2570537891 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28067227" @default.
• W2570537891 hasPublicationYear "2017" @default.
• W2570537891 type Work @default.
• W2570537891 sameAs 2570537891 @default.
• W2570537891 citedByCount "105" @default.
• W2570537891 countsByYear W25705378912017 @default.
• W2570537891 countsByYear W25705378912018 @default.
• W2570537891 countsByYear W25705378912019 @default.
• W2570537891 countsByYear W25705378912020 @default.
• W2570537891 countsByYear W25705378912021 @default.

• next