Matches in SemOpenAlex for { <https://semopenalex.org/work/W2570557273> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2570557273 endingPage "S236" @default.
- W2570557273 startingPage "S235" @default.
- W2570557273 abstract "Pulmonary adenoid cystic carcinoma (PACC) is one of the rare malignancies, that primary from glandular tissues of lung. Currently, the treatment of PACC relies on surgery and local radiotherapy. However the therapy for advanced PACC patients is limited. A larger number of studies demonstrated that advanced PACC patients obtained little benefit from chemotherapy. Moreover, only a few case reports revealed PACC patients were appropriate for target therapy. Using high-flux and high-resolution techniques to detect the genomic alterations of PACC could provide theoretical foundation for the precision therapy of PACC. 8 PACC patients who received surgical resection between January 2013 to December 2015 were enrolled. The tumor tissues from different locations and blood samples were collected. The oncoscreenTM panel by Illumina platform, which utilizing probe hybridization to gathering 287 exon regions and 22 intron regions, were used to detect the gene mutation status of PACC. And the embryonal system mutations were filtered by contrasting the gene mutation status of the leukocytes. The tumor heterogeneity was revealed by comparing the gene mutation status in different areas of the same PACC, and the phylogenetic relationships were analyzed to disclose the evolving and developing progression of PACC. There were 69 gene mutations together among 8 patients including 29 samples. Each patient has 8.6 mutations averagely. The high-frequency mutations were PAK3-D219E, FBXW7-D112E, TET2-T418I, KAT6A-E796A, and MET-R1005Q. However, the common mutations in other NSCLC, like EGFR, KRAS, ALK, etc., weren’t happened in this group of PACC. In this study, the spatial heterogeneity was discovered in PACC, not only in the mutation site, but also in the mutant abundance. Moreover, the phylogenetic relationships revealed that the clonal evolution and development existed in PACC. The status of genomic alterations in PACC was different from the other non-small cell lung cancer (NSCLC). PACC showed obvious spatial heterogeneity and clonal evolution." @default.
- W2570557273 created "2017-01-13" @default.
- W2570557273 creator A5001642071 @default.
- W2570557273 creator A5009152274 @default.
- W2570557273 creator A5021213633 @default.
- W2570557273 creator A5038651473 @default.
- W2570557273 creator A5059748830 @default.
- W2570557273 creator A5064022733 @default.
- W2570557273 creator A5067152089 @default.
- W2570557273 date "2017-01-01" @default.
- W2570557273 modified "2023-10-18" @default.
- W2570557273 title "JCES01.15 Analysis of Genomic Alterations and Heterogeneity in Pulmonary Adenoid Cystic Carcinoma by Next-Generation Sequencing" @default.
- W2570557273 doi "https://doi.org/10.1016/j.jtho.2016.11.215" @default.
- W2570557273 hasPublicationYear "2017" @default.
- W2570557273 type Work @default.
- W2570557273 sameAs 2570557273 @default.
- W2570557273 citedByCount "0" @default.
- W2570557273 crossrefType "journal-article" @default.
- W2570557273 hasAuthorship W2570557273A5001642071 @default.
- W2570557273 hasAuthorship W2570557273A5009152274 @default.
- W2570557273 hasAuthorship W2570557273A5021213633 @default.
- W2570557273 hasAuthorship W2570557273A5038651473 @default.
- W2570557273 hasAuthorship W2570557273A5059748830 @default.
- W2570557273 hasAuthorship W2570557273A5064022733 @default.
- W2570557273 hasAuthorship W2570557273A5067152089 @default.
- W2570557273 hasBestOaLocation W25705572731 @default.
- W2570557273 hasConcept C104317684 @default.
- W2570557273 hasConcept C121608353 @default.
- W2570557273 hasConcept C126322002 @default.
- W2570557273 hasConcept C127716648 @default.
- W2570557273 hasConcept C143998085 @default.
- W2570557273 hasConcept C2777546739 @default.
- W2570557273 hasConcept C2779231225 @default.
- W2570557273 hasConcept C2781187634 @default.
- W2570557273 hasConcept C36823959 @default.
- W2570557273 hasConcept C501734568 @default.
- W2570557273 hasConcept C502942594 @default.
- W2570557273 hasConcept C526805850 @default.
- W2570557273 hasConcept C54355233 @default.
- W2570557273 hasConcept C64618202 @default.
- W2570557273 hasConcept C71924100 @default.
- W2570557273 hasConcept C86803240 @default.
- W2570557273 hasConceptScore W2570557273C104317684 @default.
- W2570557273 hasConceptScore W2570557273C121608353 @default.
- W2570557273 hasConceptScore W2570557273C126322002 @default.
- W2570557273 hasConceptScore W2570557273C127716648 @default.
- W2570557273 hasConceptScore W2570557273C143998085 @default.
- W2570557273 hasConceptScore W2570557273C2777546739 @default.
- W2570557273 hasConceptScore W2570557273C2779231225 @default.
- W2570557273 hasConceptScore W2570557273C2781187634 @default.
- W2570557273 hasConceptScore W2570557273C36823959 @default.
- W2570557273 hasConceptScore W2570557273C501734568 @default.
- W2570557273 hasConceptScore W2570557273C502942594 @default.
- W2570557273 hasConceptScore W2570557273C526805850 @default.
- W2570557273 hasConceptScore W2570557273C54355233 @default.
- W2570557273 hasConceptScore W2570557273C64618202 @default.
- W2570557273 hasConceptScore W2570557273C71924100 @default.
- W2570557273 hasConceptScore W2570557273C86803240 @default.
- W2570557273 hasIssue "1" @default.
- W2570557273 hasLocation W25705572731 @default.
- W2570557273 hasOpenAccess W2570557273 @default.
- W2570557273 hasPrimaryLocation W25705572731 @default.
- W2570557273 hasRelatedWork W1966820046 @default.
- W2570557273 hasRelatedWork W2027563925 @default.
- W2570557273 hasRelatedWork W2095050670 @default.
- W2570557273 hasRelatedWork W2105073323 @default.
- W2570557273 hasRelatedWork W2136786758 @default.
- W2570557273 hasRelatedWork W2163125688 @default.
- W2570557273 hasRelatedWork W2372722177 @default.
- W2570557273 hasRelatedWork W3009829673 @default.
- W2570557273 hasRelatedWork W4206786668 @default.
- W2570557273 hasRelatedWork W4220883457 @default.
- W2570557273 hasVolume "12" @default.
- W2570557273 isParatext "false" @default.
- W2570557273 isRetracted "false" @default.
- W2570557273 magId "2570557273" @default.
- W2570557273 workType "article" @default.