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• W2570597929 abstract "Abstract To develop new whitening agents from natural products, we screened 80 compounds derived from crude drugs in Kampo medicine in a melanin synthesis inhibition assay using murine B16 melanoma cells. The screen revealed that treatment with alisol B, a triterpene from Alismatis rhizoma, significantly decreased both melanin content and cellular tyrosinase activity in B16 cells. However, alisol B did not directly inhibit mushroom tyrosinase activity in vitro. Therefore, we investigated the mechanism underlying the inhibitory effect of alisol B on melanogenesis. Alisol B suppressed mRNA induction of tyrosinase and its transcription factor, microphthalmia-associated transcription factor (MITF). Furthermore, alisol B reduced the phosphorylation of CREB and maintained the activation of ERK1/2. These results suggest that the reduction in melanin production by alisol B is due to the downregulation of MITF through the suppression of CREB and activation of ERK and that alisol B may be useful as a new whitening agent." @default.
• W2570597929 created "2017-01-13" @default.
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• W2570597929 date "2017-03-04" @default.
• W2570597929 modified "2023-09-23" @default.
• W2570597929 title "Alisol B, a triterpene from<i>Alismatis rhizoma</i>(dried rhizome of<i>Alisma orientale</i>), inhibits melanin production in murine B16 melanoma cells" @default.
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• W2570597929 doi "https://doi.org/10.1080/09168451.2016.1268042" @default.
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