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• W2570654820 abstract "The key mediator of the innate physiological stress response has long been hypothesized to be the hypothalamic peptide corticotropin-releasing factor (CRF). This 41 amino acid peptide modulates the endocrine, autonomic, behavioral, and immune responses to stress through actions at specific receptors both in the central nervous system as well as the periphery. These seven transmembrane proteins belong to the superfamily of G protein–coupled receptors and play a role in central nervous system, cardiovascular, gastrointestinal, and pituitary-adrenal function. Decades of research have implied a direct relationship between stress-related disorders and CRF activity in the brain. As a result, this system has been the focus of many drug discovery programs aimed at identifying selective and specific orally active molecules that can block the pathophysiological increase in activity of this peptide. This review will summarize this system, the evidence supporting the utility of molecules that block the CRF system in human disease and the current state of the drug discovery programs that have yet to produce a viable therapeutic." @default.
• W2570654820 created "2017-01-13" @default.
• W2570654820 creator A5052614648 @default.
• W2570654820 date "2017-01-01" @default.
• W2570654820 modified "2023-09-23" @default.
• W2570654820 title "Corticotropin-Releasing Factor and Urocortin Receptors" @default.
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• W2570654820 doi "https://doi.org/10.1016/b978-0-12-802175-0.00006-1" @default.
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