FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2570660323> ?p ?o ?g. }

• W2570660323 endingPage "e0005234" @default.
• W2570660323 startingPage "e0005234" @default.
• W2570660323 abstract "Host-directed therapies (HDTs) constitute promising alternatives to traditional therapy that directly targets the pathogen but is often hampered by pathogen resistance. HDT could represent a new treatment strategy for leishmaniasis, a neglected tropical disease caused by the obligate intracellular parasite Leishmania. This protozoan develops exclusively within phagocytic cells, where infection relies on a complex molecular interplay potentially exploitable for drug targets. We previously identified naloxonazine, a compound specifically active against intracellular but not axenic Leishmania donovani. We evaluated here whether this compound could present a host cell-dependent mechanism of action. Microarray profiling of THP-1 macrophages treated with naloxonazine showed upregulation of vATPases, which was further linked to an increased volume of intracellular acidic vacuoles. Treatment of Leishmania-infected macrophages with the vATPase inhibitor concanamycin A abolished naloxonazine effects, functionally demonstrating that naloxonazine affects Leishmania amastigotes indirectly, through host cell vacuolar remodeling. These results validate amastigote-specific screening approaches as a powerful way to identify alternative host-encoded targets. Although the therapeutic value of naloxonazine itself is unproven, our results further demonstrate the importance of intracellular acidic compartments for host defense against Leishmania, highlighting the possibility of targeting this host cell compartment for anti-leishmanial therapy." @default.
• W2570660323 created "2017-01-13" @default.
• W2570660323 creator A5028291807 @default.
• W2570660323 creator A5050856602 @default.
• W2570660323 creator A5054138064 @default.
• W2570660323 creator A5057998514 @default.
• W2570660323 creator A5059067751 @default.
• W2570660323 creator A5064901452 @default.
• W2570660323 date "2016-12-30" @default.
• W2570660323 modified "2023-10-03" @default.
• W2570660323 title "Naloxonazine, an Amastigote-Specific Compound, Affects Leishmania Parasites through Modulation of Host-Encoded Functions" @default.
• W2570660323 cites W1612419598 @default.
• W2570660323 cites W1833793080 @default.
• W2570660323 cites W1964607061 @default.
• W2570660323 cites W1973577139 @default.
• W2570660323 cites W1980411188 @default.
• W2570660323 cites W2015307962 @default.
• W2570660323 cites W2017699535 @default.
• W2570660323 cites W2024396003 @default.
• W2570660323 cites W2035555452 @default.
• W2570660323 cites W2048067023 @default.
• W2570660323 cites W2057260347 @default.
• W2570660323 cites W2060295594 @default.
• W2570660323 cites W2074505948 @default.
• W2570660323 cites W2077508307 @default.
• W2570660323 cites W2113179494 @default.
• W2570660323 cites W2118693452 @default.
• W2570660323 cites W2120307572 @default.
• W2570660323 cites W2125483721 @default.
• W2570660323 cites W2126812590 @default.
• W2570660323 cites W2130967505 @default.
• W2570660323 cites W2133465414 @default.
• W2570660323 cites W2136000113 @default.
• W2570660323 cites W2143119706 @default.
• W2570660323 cites W2150893994 @default.
• W2570660323 cites W2158217645 @default.
• W2570660323 cites W2158501592 @default.
• W2570660323 cites W2158664225 @default.
• W2570660323 cites W2206419368 @default.
• W2570660323 doi "https://doi.org/10.1371/journal.pntd.0005234" @default.
• W2570660323 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5201425" @default.
• W2570660323 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28036391" @default.
• W2570660323 hasPublicationYear "2016" @default.
• W2570660323 type Work @default.
• W2570660323 sameAs 2570660323 @default.
• W2570660323 citedByCount "17" @default.
• W2570660323 countsByYear W25706603232017 @default.
• W2570660323 countsByYear W25706603232018 @default.
• W2570660323 countsByYear W25706603232019 @default.
• W2570660323 countsByYear W25706603232020 @default.
• W2570660323 countsByYear W25706603232021 @default.
• W2570660323 countsByYear W25706603232022 @default.
• W2570660323 crossrefType "journal-article" @default.
• W2570660323 hasAuthorship W2570660323A5028291807 @default.
• W2570660323 hasAuthorship W2570660323A5050856602 @default.
• W2570660323 hasAuthorship W2570660323A5054138064 @default.
• W2570660323 hasAuthorship W2570660323A5057998514 @default.
• W2570660323 hasAuthorship W2570660323A5059067751 @default.
• W2570660323 hasAuthorship W2570660323A5064901452 @default.
• W2570660323 hasBestOaLocation W25706603231 @default.
• W2570660323 hasConcept C136764020 @default.
• W2570660323 hasConcept C153726182 @default.
• W2570660323 hasConcept C202751555 @default.
• W2570660323 hasConcept C203014093 @default.
• W2570660323 hasConcept C2776460866 @default.
• W2570660323 hasConcept C2776555147 @default.
• W2570660323 hasConcept C2778265057 @default.
• W2570660323 hasConcept C2778689377 @default.
• W2570660323 hasConcept C2779244956 @default.
• W2570660323 hasConcept C2781092759 @default.
• W2570660323 hasConcept C2781333301 @default.
• W2570660323 hasConcept C41008148 @default.
• W2570660323 hasConcept C523546767 @default.
• W2570660323 hasConcept C54355233 @default.
• W2570660323 hasConcept C71928629 @default.
• W2570660323 hasConcept C79879829 @default.
• W2570660323 hasConcept C86803240 @default.
• W2570660323 hasConcept C89423630 @default.
• W2570660323 hasConcept C95444343 @default.
• W2570660323 hasConcept C98319499 @default.
• W2570660323 hasConceptScore W2570660323C136764020 @default.
• W2570660323 hasConceptScore W2570660323C153726182 @default.
• W2570660323 hasConceptScore W2570660323C202751555 @default.
• W2570660323 hasConceptScore W2570660323C203014093 @default.
• W2570660323 hasConceptScore W2570660323C2776460866 @default.
• W2570660323 hasConceptScore W2570660323C2776555147 @default.
• W2570660323 hasConceptScore W2570660323C2778265057 @default.
• W2570660323 hasConceptScore W2570660323C2778689377 @default.
• W2570660323 hasConceptScore W2570660323C2779244956 @default.
• W2570660323 hasConceptScore W2570660323C2781092759 @default.
• W2570660323 hasConceptScore W2570660323C2781333301 @default.
• W2570660323 hasConceptScore W2570660323C41008148 @default.
• W2570660323 hasConceptScore W2570660323C523546767 @default.
• W2570660323 hasConceptScore W2570660323C54355233 @default.
• W2570660323 hasConceptScore W2570660323C71928629 @default.
• W2570660323 hasConceptScore W2570660323C79879829 @default.
• W2570660323 hasConceptScore W2570660323C86803240 @default.
• W2570660323 hasConceptScore W2570660323C89423630 @default.

• next