Matches in SemOpenAlex for { <https://semopenalex.org/work/W2570664036> ?p ?o ?g. }
- W2570664036 endingPage "104" @default.
- W2570664036 startingPage "104" @default.
- W2570664036 abstract "In the era of precision medicine, more attention is paid to the search for predictive markers of treatment efficacy and tolerability. Statins are one of the classes of drugs that could benefit from this approach because of their wide use and their incidence of adverse events.Literature from PubMed databases and bibliography from retrieved publications have been analyzed according to terms such as statins, pharmacogenetics, epigenetics, toxicity and drug-drug interaction, among others. The search was performed until 1 October 2016 for articles published in English language.Several technical and methodological approaches have been adopted, including candidate gene and next generation sequencing (NGS) analyses, the latter being more robust and reliable. Among genes identified as possible predictive factors associated with statins toxicity, cytochrome P450 isoforms, transmembrane transporters and mitochondrial enzymes are the best characterized. Finally, the solute carrier organic anion transporter family member 1B1 (SLCO1B1) transporter seems to be the best target for future studies. Moreover, drug-drug interactions need to be considered for the best approach to personalized treatment.Pharmacogenetics of statins includes several possible genes and their polymorphisms, but muscular toxicities seem better related to SLCO1B1 variant alleles. Their analysis in the general population of patients taking statins could improve treatment adherence and efficacy; however, the cost-efficacy ratio should be carefully evaluated." @default.
- W2570664036 created "2017-01-13" @default.
- W2570664036 creator A5013528946 @default.
- W2570664036 creator A5030848899 @default.
- W2570664036 creator A5037889066 @default.
- W2570664036 creator A5061906330 @default.
- W2570664036 creator A5068107707 @default.
- W2570664036 creator A5083693387 @default.
- W2570664036 date "2017-01-06" @default.
- W2570664036 modified "2023-10-04" @default.
- W2570664036 title "Pharmacogenetic Foundations of Therapeutic Efficacy and Adverse Events of Statins" @default.
- W2570664036 cites W1149098462 @default.
- W2570664036 cites W1151947662 @default.
- W2570664036 cites W1485586051 @default.
- W2570664036 cites W1535419643 @default.
- W2570664036 cites W1580430519 @default.
- W2570664036 cites W1604547439 @default.
- W2570664036 cites W166447872 @default.
- W2570664036 cites W1783939843 @default.
- W2570664036 cites W1811890859 @default.
- W2570664036 cites W1816597323 @default.
- W2570664036 cites W1916071341 @default.
- W2570664036 cites W1923201889 @default.
- W2570664036 cites W1963672344 @default.
- W2570664036 cites W1963958736 @default.
- W2570664036 cites W1964240590 @default.
- W2570664036 cites W1970750464 @default.
- W2570664036 cites W1985219174 @default.
- W2570664036 cites W1986910923 @default.
- W2570664036 cites W1987478572 @default.
- W2570664036 cites W1993151230 @default.
- W2570664036 cites W1994350860 @default.
- W2570664036 cites W1995213656 @default.
- W2570664036 cites W1996359690 @default.
- W2570664036 cites W1997991790 @default.
- W2570664036 cites W1998137132 @default.
- W2570664036 cites W1998436936 @default.
- W2570664036 cites W1999483586 @default.
- W2570664036 cites W2000093141 @default.
- W2570664036 cites W2000484916 @default.
- W2570664036 cites W2005433404 @default.
- W2570664036 cites W2005776262 @default.
- W2570664036 cites W2014565106 @default.
- W2570664036 cites W2015699998 @default.
- W2570664036 cites W2016562008 @default.
- W2570664036 cites W2016814341 @default.
- W2570664036 cites W2017098712 @default.
- W2570664036 cites W2021103317 @default.
- W2570664036 cites W2022626418 @default.
- W2570664036 cites W2023145763 @default.
- W2570664036 cites W2023253645 @default.
- W2570664036 cites W2024981560 @default.
- W2570664036 cites W2025139957 @default.
- W2570664036 cites W2025162232 @default.
- W2570664036 cites W2025625383 @default.
- W2570664036 cites W2025801982 @default.
- W2570664036 cites W2027504487 @default.
- W2570664036 cites W2028447671 @default.
- W2570664036 cites W2030663513 @default.
- W2570664036 cites W2032860698 @default.
- W2570664036 cites W2033417180 @default.
- W2570664036 cites W2036984665 @default.
- W2570664036 cites W2038989721 @default.
- W2570664036 cites W2039448072 @default.
- W2570664036 cites W2039986849 @default.
- W2570664036 cites W2040502237 @default.
- W2570664036 cites W2043263931 @default.
- W2570664036 cites W2043432548 @default.
- W2570664036 cites W2044603165 @default.
- W2570664036 cites W2044826589 @default.
- W2570664036 cites W2047207059 @default.
- W2570664036 cites W2047229228 @default.
- W2570664036 cites W2048534498 @default.
- W2570664036 cites W2049619885 @default.
- W2570664036 cites W2051371418 @default.
- W2570664036 cites W2053891541 @default.
- W2570664036 cites W2056754054 @default.
- W2570664036 cites W2063525364 @default.
- W2570664036 cites W2071981052 @default.
- W2570664036 cites W2075597058 @default.
- W2570664036 cites W2075660879 @default.
- W2570664036 cites W2075728036 @default.
- W2570664036 cites W2078193322 @default.
- W2570664036 cites W2079710733 @default.
- W2570664036 cites W2085265604 @default.
- W2570664036 cites W2085658412 @default.
- W2570664036 cites W2087278907 @default.
- W2570664036 cites W2089308595 @default.
- W2570664036 cites W2094245324 @default.
- W2570664036 cites W2094858401 @default.
- W2570664036 cites W2095010499 @default.
- W2570664036 cites W2097510503 @default.
- W2570664036 cites W2100954028 @default.
- W2570664036 cites W2103016451 @default.
- W2570664036 cites W2103873642 @default.
- W2570664036 cites W2104465297 @default.
- W2570664036 cites W2104689123 @default.
- W2570664036 cites W2105299596 @default.