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- W2570687430 abstract "Simple, accurate, sensitive and validated UV stability-indicating spectrophotometric and chemometric methods were developed for determination of CitalopramHydrobromide (CT) in presence of its alkaline, oxidative degradation products and in its pharmaceutical preparation. Method (A) is a successive derivative ratio spectrophotometricone, which depends on the successive derivative of ratio spectra in two steps andmeasuring Citalopram Hydrobromide at 277nmand 293nm.Method (B) ismean centering of ratio spectra which dependson using the mean centered ratio spectra in two successive steps and measuring the mean centeredvalues of the second ratio spectra at 237nm and method (C) used two chemometric techniques ; principal component regression(PCR) and partial least-squares (PLS). The proposed methods werechecked using laboratory-prepared mixtures and were successfully applied for the analysis of pharmaceuticalformulation containing Citalopram Hydrobromide. The proposed methods were validated according to the ICH guidelines. The obtained results were statistically comparedwith those obtained froma compendialHPLCmethod, showing no significant difference with respect to accuracy and precision." @default.
- W2570687430 created "2017-01-13" @default.
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- W2570687430 date "2015-07-22" @default.
- W2570687430 modified "2023-09-27" @default.
- W2570687430 title "Quantitative Determination of Citalopram Hydrobromide by Spectrophotometry and Chemometry in Presence of Its Degradation Products and Additives in Pharmaceutical Preparation" @default.
- W2570687430 doi "https://doi.org/10.15242/iicbe.c0715105" @default.
- W2570687430 hasPublicationYear "2015" @default.
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