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- W2570688550 abstract "NSCLC is the leading cause of cancer death in today’s scenario. Despite significant progress in early stage disease, survival rates for advanced disease remain low. Platinumbased doublet chemotherapy has become the current standard of care for advanced nonsmall cell lung cancer (NSCLC) which has shown modest prolongation of survival and improvement in cancerrelated symptoms. All the patients received [email protected] 500mg/m2 Day 1 and Cisplatin @ 75mg/m2 every 21 days with restaging after 3 and 6 cycles. Overall response rate was the primary end point and PFS as secondary end point. In this retrospective study, 90 patients were analyzed. The patients treated with pemetrexed plus cisplatin had a median age of 58 years and were predominantly men (70) with nonsquamous histology (60), stage IV (52) disease, and a performance status of 0 (40). Response rates were 48%. Median time to progression was 7 months. Median overall survival was 12 months. The 1year survival rate was 52%. Hematologic toxicities observed in the patients were grade 3/4 neutropenia (20%), grade 3 thrombocytopenia (10%), and grade 3 anemia (6%). Ten patients had febrile neutropenia. The combination of pemetrexed and cisplatin was effective and safe and associated with acceptable toxicities and relatively long survival in patienst with advanced NSCLC." @default.
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- W2570688550 date "2017-01-01" @default.
- W2570688550 modified "2023-10-11" @default.
- W2570688550 title "PUB039 Role of Pemetrexed and Cisplatin Combination Therapy in Advanced Non Squamous Cell Lung Cancer" @default.
- W2570688550 doi "https://doi.org/10.1016/j.jtho.2016.11.2009" @default.
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