FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2570767573> ?p ?o ?g. }

• W2570767573 endingPage "1405" @default.
• W2570767573 startingPage "1394" @default.
• W2570767573 abstract "Astrocytes play a key role in brain homeostasis, protecting neurons against neurotoxic stimuli such as oxidative stress. Therefore, the neuroprotective therapeutics that enhance astrocytic functionality has been regarded as a promising strategy to reduce brain damage. We previously reported that ciclopirox, a well-known antifungal N-hydroxypyridone compound, protects astrocytes from oxidative stress by enhancing mitochondrial function. Using the N-hydroxypyridone scaffold, we have synthesized a series of cytoprotective derivatives. Mitochondrial activity assay showed that N-hydroxypyridone derivatives with biphenyl group have comparable to better protective effects than ciclopirox in astrocytes exposed to H2O2. N-hydroxypyridone derivatives, especially 11g, inhibited H2O2-induced deterioration of mitochondrial membrane potential and oxygen consumption rate, and significantly improved cell viability of astrocytes. The results indicate that the N-hydroxypyridone motif can provide a novel cytoprotective scaffold for astrocytes via enhancing mitochondrial functionality." @default.
• W2570767573 created "2017-01-13" @default.
• W2570767573 creator A5000551501 @default.
• W2570767573 creator A5002587541 @default.
• W2570767573 creator A5020099959 @default.
• W2570767573 creator A5035611667 @default.
• W2570767573 creator A5037333086 @default.
• W2570767573 creator A5046281788 @default.
• W2570767573 creator A5051733146 @default.
• W2570767573 creator A5062241815 @default.
• W2570767573 creator A5068544949 @default.
• W2570767573 creator A5080346539 @default.
• W2570767573 creator A5084188626 @default.
• W2570767573 creator A5086997080 @default.
• W2570767573 date "2017-02-01" @default.
• W2570767573 modified "2023-09-24" @default.
• W2570767573 title "Discovery of a novel series of N -hydroxypyridone derivatives protecting astrocytes against hydrogen peroxide-induced toxicity via improved mitochondrial functionality" @default.
• W2570767573 cites W1514606780 @default.
• W2570767573 cites W1964473737 @default.
• W2570767573 cites W1965396662 @default.
• W2570767573 cites W1974420316 @default.
• W2570767573 cites W1994986552 @default.
• W2570767573 cites W2003978196 @default.
• W2570767573 cites W2005598450 @default.
• W2570767573 cites W2005896958 @default.
• W2570767573 cites W2023096091 @default.
• W2570767573 cites W2041874445 @default.
• W2570767573 cites W2042110352 @default.
• W2570767573 cites W2048830349 @default.
• W2570767573 cites W2055285423 @default.
• W2570767573 cites W2057879028 @default.
• W2570767573 cites W2059290659 @default.
• W2570767573 cites W2066874732 @default.
• W2570767573 cites W2070621017 @default.
• W2570767573 cites W2084017433 @default.
• W2570767573 cites W2087801534 @default.
• W2570767573 cites W2093370096 @default.
• W2570767573 cites W2099026515 @default.
• W2570767573 cites W2099456670 @default.
• W2570767573 cites W2111274361 @default.
• W2570767573 cites W2111972561 @default.
• W2570767573 cites W2118405368 @default.
• W2570767573 cites W2134648110 @default.
• W2570767573 cites W2138288799 @default.
• W2570767573 cites W2304707465 @default.
• W2570767573 cites W2325146770 @default.
• W2570767573 cites W2952126372 @default.
• W2570767573 doi "https://doi.org/10.1016/j.bmc.2016.12.052" @default.
• W2570767573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28089588" @default.
• W2570767573 hasPublicationYear "2017" @default.
• W2570767573 type Work @default.
• W2570767573 sameAs 2570767573 @default.
• W2570767573 citedByCount "5" @default.
• W2570767573 countsByYear W25707675732017 @default.
• W2570767573 countsByYear W25707675732018 @default.
• W2570767573 countsByYear W25707675732020 @default.
• W2570767573 countsByYear W25707675732021 @default.
• W2570767573 crossrefType "journal-article" @default.
• W2570767573 hasAuthorship W2570767573A5000551501 @default.
• W2570767573 hasAuthorship W2570767573A5002587541 @default.
• W2570767573 hasAuthorship W2570767573A5020099959 @default.
• W2570767573 hasAuthorship W2570767573A5035611667 @default.
• W2570767573 hasAuthorship W2570767573A5037333086 @default.
• W2570767573 hasAuthorship W2570767573A5046281788 @default.
• W2570767573 hasAuthorship W2570767573A5051733146 @default.
• W2570767573 hasAuthorship W2570767573A5062241815 @default.
• W2570767573 hasAuthorship W2570767573A5068544949 @default.
• W2570767573 hasAuthorship W2570767573A5080346539 @default.
• W2570767573 hasAuthorship W2570767573A5084188626 @default.
• W2570767573 hasAuthorship W2570767573A5086997080 @default.
• W2570767573 hasConcept C1491633281 @default.
• W2570767573 hasConcept C185592680 @default.
• W2570767573 hasConcept C25498285 @default.
• W2570767573 hasConcept C2776151105 @default.
• W2570767573 hasConcept C28859421 @default.
• W2570767573 hasConcept C48349386 @default.
• W2570767573 hasConcept C53227056 @default.
• W2570767573 hasConcept C533411734 @default.
• W2570767573 hasConcept C55493867 @default.
• W2570767573 hasConcept C86803240 @default.
• W2570767573 hasConcept C95444343 @default.
• W2570767573 hasConcept C98274493 @default.
• W2570767573 hasConceptScore W2570767573C1491633281 @default.
• W2570767573 hasConceptScore W2570767573C185592680 @default.
• W2570767573 hasConceptScore W2570767573C25498285 @default.
• W2570767573 hasConceptScore W2570767573C2776151105 @default.
• W2570767573 hasConceptScore W2570767573C28859421 @default.
• W2570767573 hasConceptScore W2570767573C48349386 @default.
• W2570767573 hasConceptScore W2570767573C53227056 @default.
• W2570767573 hasConceptScore W2570767573C533411734 @default.
• W2570767573 hasConceptScore W2570767573C55493867 @default.
• W2570767573 hasConceptScore W2570767573C86803240 @default.
• W2570767573 hasConceptScore W2570767573C95444343 @default.
• W2570767573 hasConceptScore W2570767573C98274493 @default.
• W2570767573 hasFunder F4320322120 @default.
• W2570767573 hasIssue "4" @default.
• W2570767573 hasLocation W25707675731 @default.
• W2570767573 hasLocation W25707675732 @default.

• next