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- W2570793562 abstract "The importance of biological target-based studies is currently highlighted by impressive objective response rates (ORRs) and longer progression-free survivals (PFSs) provided by epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) compared with cytotoxic chemotherapies in the treatment of EGFR mutated non-small cell lung cancer (NSCLC) patients and, more recently, by anaplastic lymphoma kinase inhibitors (ALK-Is) in ALK-rearranged NSCLC ones (1-4). As a consequence, recent therapeutic research strategies in NSCLC, particularly in lung adenocarcinoma, focused on innovative potential molecular targets such as KRAS, BRAF, HER2, PIK3CA, and others in frequencies exceeding 1% (5)." @default.
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- W2570793562 date "2016-12-29" @default.
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- W2570793562 title "BRAF inhibitors in advanced BRAF-positive non-small cell lung cancer" @default.
- W2570793562 doi "https://doi.org/10.21037/11284" @default.
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