FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2570956126> ?p ?o ?g. }

• W2570956126 endingPage "17" @default.
• W2570956126 startingPage "1" @default.
• W2570956126 abstract "Mechanisms of interleukin-6 (IL-6)-induced cortisol release (CR) were investigated by exposing H295R cells to IL-6 and determining mRNA/protein expression (PCR/western blots) for steroidogenic enzymes (SE), steroidogenic acute regulatory protein (StAR), steroidogenic factor-1 (SF-1) (enhances SE/StAR expression), activator protein 1 (AP-1) (regulates SE/StAR expression) and adrenal hypoplasia congenita-like protein (DAX-1) (inhibits SE/StAR expression). Promoter activity of StAR (SPA) was measured by a luciferase-coupled promoter. Cortisol release was increased by 10 ng/mL IL-6 (24 h P < 0.01). Proteins/mRNAs (StAR, cholesterol side chain cleavage enzyme, SF-1, AP-1) and SPA were increased by IL-6 (60 min 1–50 ng/mL IL-6; 5 ng/mL IL-6 30–120 min P < 0.05). Four other SE proteins/mRNAs were also increased by 10 ng/mL IL-6 (60 min P < 0.01). Protein/mRNA for DAX-1 was decreased by IL-6 (60 min 1–50 ng/mL IL-6; 5 ng/mL IL-6 30–120 min P < 0.01). Phosphorylation of Janus kinase (JAK) and signal transducer and activator of transcription (STAT) was increased by IL-6 (JAK2 60 min 1–50 ng/mL IL-6; 10 ng/mL IL-6 5–60 min P < 0.05; STAT1 and STAT3 60 min 10 ng/mL IL-6 P < 0.01). Inhibition of JAK/STAT with AG490 (10 μM) or piceatannol (50 μM) blocked (P < 0.01 10 ng/mL IL-6 vs. IL-6 plus AG490 or piceatannol) IL-6-induced increases in SPA and StAR mRNA. In summary, IL-6-induced CR may be facilitated by increased StAR and SE mediated by increased SF-1 and AP-1, decreased DAX-1, and increased phosphorylation of JAK/STAT." @default.
• W2570956126 created "2017-01-13" @default.
• W2570956126 creator A5007800012 @default.
• W2570956126 creator A5047060365 @default.
• W2570956126 creator A5077158086 @default.
• W2570956126 creator A5081746946 @default.
• W2570956126 creator A5081864113 @default.
• W2570956126 creator A5086257612 @default.
• W2570956126 date "2017-03-01" @default.
• W2570956126 modified "2023-09-27" @default.
• W2570956126 title "Interleukin-6 increases the expression of key proteins associated with steroidogenesis in human NCI-H295R adrenocortical cells" @default.
• W2570956126 cites W1532041675 @default.
• W2570956126 cites W1806394871 @default.
• W2570956126 cites W1824426416 @default.
• W2570956126 cites W1963854253 @default.
• W2570956126 cites W1981078229 @default.
• W2570956126 cites W1981234399 @default.
• W2570956126 cites W1990193384 @default.
• W2570956126 cites W1990461493 @default.
• W2570956126 cites W1991579668 @default.
• W2570956126 cites W1991862686 @default.
• W2570956126 cites W1999182152 @default.
• W2570956126 cites W2000781996 @default.
• W2570956126 cites W2001977708 @default.
• W2570956126 cites W2009171847 @default.
• W2570956126 cites W2010177716 @default.
• W2570956126 cites W2011685524 @default.
• W2570956126 cites W2026374274 @default.
• W2570956126 cites W2029761100 @default.
• W2570956126 cites W2030014151 @default.
• W2570956126 cites W2033550124 @default.
• W2570956126 cites W2038220228 @default.
• W2570956126 cites W2046096150 @default.
• W2570956126 cites W2047959573 @default.
• W2570956126 cites W2060610536 @default.
• W2570956126 cites W2066392991 @default.
• W2570956126 cites W2071244646 @default.
• W2570956126 cites W2084655958 @default.
• W2570956126 cites W2085728744 @default.
• W2570956126 cites W2085742201 @default.
• W2570956126 cites W2086385504 @default.
• W2570956126 cites W2088887274 @default.
• W2570956126 cites W2091270313 @default.
• W2570956126 cites W2093386301 @default.
• W2570956126 cites W2093736214 @default.
• W2570956126 cites W2096846771 @default.
• W2570956126 cites W2098031897 @default.
• W2570956126 cites W2099662728 @default.
• W2570956126 cites W2107277218 @default.
• W2570956126 cites W2121904756 @default.
• W2570956126 cites W2125515425 @default.
• W2570956126 cites W2128631462 @default.
• W2570956126 cites W2135989782 @default.
• W2570956126 cites W2143305123 @default.
• W2570956126 cites W2146693123 @default.
• W2570956126 cites W2151823339 @default.
• W2570956126 doi "https://doi.org/10.1016/j.steroids.2016.12.014" @default.
• W2570956126 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28063793" @default.
• W2570956126 hasPublicationYear "2017" @default.
• W2570956126 type Work @default.
• W2570956126 sameAs 2570956126 @default.
• W2570956126 citedByCount "10" @default.
• W2570956126 countsByYear W25709561262017 @default.
• W2570956126 countsByYear W25709561262018 @default.
• W2570956126 countsByYear W25709561262019 @default.
• W2570956126 countsByYear W25709561262020 @default.
• W2570956126 countsByYear W25709561262021 @default.
• W2570956126 countsByYear W25709561262022 @default.
• W2570956126 crossrefType "journal-article" @default.
• W2570956126 hasAuthorship W2570956126A5007800012 @default.
• W2570956126 hasAuthorship W2570956126A5047060365 @default.
• W2570956126 hasAuthorship W2570956126A5077158086 @default.
• W2570956126 hasAuthorship W2570956126A5081746946 @default.
• W2570956126 hasAuthorship W2570956126A5081864113 @default.
• W2570956126 hasAuthorship W2570956126A5086257612 @default.
• W2570956126 hasConcept C104317684 @default.
• W2570956126 hasConcept C105580179 @default.
• W2570956126 hasConcept C126322002 @default.
• W2570956126 hasConcept C134018914 @default.
• W2570956126 hasConcept C153911025 @default.
• W2570956126 hasConcept C170493617 @default.
• W2570956126 hasConcept C171958077 @default.
• W2570956126 hasConcept C185592680 @default.
• W2570956126 hasConcept C2778923194 @default.
• W2570956126 hasConcept C2779670467 @default.
• W2570956126 hasConcept C55493867 @default.
• W2570956126 hasConcept C62478195 @default.
• W2570956126 hasConcept C71924100 @default.
• W2570956126 hasConcept C80446465 @default.
• W2570956126 hasConcept C86803240 @default.
• W2570956126 hasConcept C88045685 @default.
• W2570956126 hasConceptScore W2570956126C104317684 @default.
• W2570956126 hasConceptScore W2570956126C105580179 @default.
• W2570956126 hasConceptScore W2570956126C126322002 @default.
• W2570956126 hasConceptScore W2570956126C134018914 @default.
• W2570956126 hasConceptScore W2570956126C153911025 @default.
• W2570956126 hasConceptScore W2570956126C170493617 @default.
• W2570956126 hasConceptScore W2570956126C171958077 @default.

• next