FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2571016552> ?p ?o ?g. }

• W2571016552 endingPage "491" @default.
• W2571016552 startingPage "481" @default.
• W2571016552 abstract "Summary There is evidence that low‐grade inflammation may be responsible for pain and development of degenerative changes in temporomandibular joint internal derangement. This article reviews the current knowledge of the molecular mechanisms behind TMJ internal derangements. A non‐systematic search was carried out in PubMed, Embase and the Cochrane library for studies regarding pathophysiological mechanisms behind internal derangements focusing on pain‐mediating inflammatory and cartilage‐degrading molecules. Recent data suggest that release of cytokines may be the key event for pain and cartilage destruction in TMJ internal derangements. Cytokines promote the release of matrix metalloproteinases ( MMP s), and due to hypoxia, vascular endothelial growth factor ( VEGF ) is released. This activates chondrocytes to produce MMP s and reduce their tissue inhibitors ( TIMP s) as well as the recruitment of osteoclasts, ultimately leading to cartilage and bone resorption. Also, proteoglycans have an important role in this process. Several cytokines, MMP s, TIMP s and VEGF have been identified in higher concentrations in the TMJ synovial fluid of patients with painful internal derangements and shown to be associated with the degree of degeneration. Other molecules that show elevated levels include hyaluronic acid synthase, disintegrin and metalloproteinase with thrombospondin motifs ( ADAMT s), aggrecan, fibromodulin, biglycan and lumican. Taken together, more or less pronounced inflammation of TMJ structures with release of cytokines, MMP s and other molecular markers that interact in a complex manner may be responsible for tissue degeneration in internal derangements. As internal derangements may be symptom‐free, the degree of inflammation, but also other mechanisms, may be important for pain development." @default.
• W2571016552 created "2017-01-13" @default.
• W2571016552 creator A5009758954 @default.
• W2571016552 date "2017-01-30" @default.
• W2571016552 modified "2023-10-04" @default.
• W2571016552 title "The role of molecular pain biomarkers in temporomandibular joint internal derangement" @default.
• W2571016552 cites W194866021 @default.
• W2571016552 cites W1964573517 @default.
• W2571016552 cites W1965804451 @default.
• W2571016552 cites W1966109142 @default.
• W2571016552 cites W1966599120 @default.
• W2571016552 cites W1967760855 @default.
• W2571016552 cites W1969731852 @default.
• W2571016552 cites W1971045736 @default.
• W2571016552 cites W1972739644 @default.
• W2571016552 cites W1974991167 @default.
• W2571016552 cites W1974996960 @default.
• W2571016552 cites W1980220254 @default.
• W2571016552 cites W1985654808 @default.
• W2571016552 cites W1997272733 @default.
• W2571016552 cites W2000564150 @default.
• W2571016552 cites W2000718317 @default.
• W2571016552 cites W2002338338 @default.
• W2571016552 cites W2004648051 @default.
• W2571016552 cites W2007557616 @default.
• W2571016552 cites W2008038175 @default.
• W2571016552 cites W2009244370 @default.
• W2571016552 cites W2011545725 @default.
• W2571016552 cites W2017822480 @default.
• W2571016552 cites W2018332089 @default.
• W2571016552 cites W2020162257 @default.
• W2571016552 cites W2020654418 @default.
• W2571016552 cites W2029024971 @default.
• W2571016552 cites W2029231891 @default.
• W2571016552 cites W2031575466 @default.
• W2571016552 cites W2031674537 @default.
• W2571016552 cites W2036622789 @default.
• W2571016552 cites W2037245148 @default.
• W2571016552 cites W2039663310 @default.
• W2571016552 cites W2040099336 @default.
• W2571016552 cites W2044248313 @default.
• W2571016552 cites W2044508217 @default.
• W2571016552 cites W2049119590 @default.
• W2571016552 cites W2049893021 @default.
• W2571016552 cites W2050789938 @default.
• W2571016552 cites W2052270361 @default.
• W2571016552 cites W2053814922 @default.
• W2571016552 cites W2055455956 @default.
• W2571016552 cites W2058936679 @default.
• W2571016552 cites W2059818758 @default.
• W2571016552 cites W2060721022 @default.
• W2571016552 cites W2063945805 @default.
• W2571016552 cites W2064935195 @default.
• W2571016552 cites W2065351856 @default.
• W2571016552 cites W2066235886 @default.
• W2571016552 cites W2072527296 @default.
• W2571016552 cites W2073319736 @default.
• W2571016552 cites W2074175240 @default.
• W2571016552 cites W2074599094 @default.
• W2571016552 cites W2077695586 @default.
• W2571016552 cites W2078529589 @default.
• W2571016552 cites W2079217829 @default.
• W2571016552 cites W2080344305 @default.
• W2571016552 cites W2085939150 @default.
• W2571016552 cites W2088194491 @default.
• W2571016552 cites W2089377390 @default.
• W2571016552 cites W2092341998 @default.
• W2571016552 cites W2097688808 @default.
• W2571016552 cites W2101117814 @default.
• W2571016552 cites W2103868159 @default.
• W2571016552 cites W2103949219 @default.
• W2571016552 cites W2108539579 @default.
• W2571016552 cites W2117139373 @default.
• W2571016552 cites W2128478642 @default.
• W2571016552 cites W2130163012 @default.
• W2571016552 cites W2134260905 @default.
• W2571016552 cites W2149955231 @default.
• W2571016552 cites W2156735189 @default.
• W2571016552 cites W2158648177 @default.
• W2571016552 cites W2159228692 @default.
• W2571016552 cites W2162427168 @default.
• W2571016552 cites W2162780592 @default.
• W2571016552 cites W2223288411 @default.
• W2571016552 cites W2395218077 @default.
• W2571016552 cites W4241786477 @default.
• W2571016552 doi "https://doi.org/10.1111/joor.12480" @default.
• W2571016552 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28054366" @default.
• W2571016552 hasPublicationYear "2017" @default.
• W2571016552 type Work @default.
• W2571016552 sameAs 2571016552 @default.
• W2571016552 citedByCount "36" @default.
• W2571016552 countsByYear W25710165522018 @default.
• W2571016552 countsByYear W25710165522019 @default.
• W2571016552 countsByYear W25710165522020 @default.
• W2571016552 countsByYear W25710165522021 @default.
• W2571016552 countsByYear W25710165522022 @default.
• W2571016552 countsByYear W25710165522023 @default.
• W2571016552 crossrefType "journal-article" @default.

• next