FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2571120723> ?p ?o ?g. }

• W2571120723 abstract "Cell therapy for intrinsic urinary sphincter deficiency (ISD) in women has been moderately effective, and improvements are needed. To improve treatment efficacy, it is important to better understand determinates of cell efficacy in the different patient cohorts. We have reported that in nonhuman primates the chronicity of ISD may affect cell efficacy, but additional factors (age, psychosocial stress, hormone status, body weight) can be associated with many disease/treatment outcomes in women – and these factors are the focus of this study. Adult female cynomolgus monkeys were divided into groups: (1) younger (n = 10, 5–8 years of age) versus older (n = 10, 13–18 years of age); (2) age-matched/socially subordinate (n = 15) versus socially dominant (n = 15); and (3) age-matched lower body weight (n = 6) versus higher body weight (n = 6). Autologous skeletal muscle precursor cells (skMPCs, 5 million) were injected into the urinary sphincter 6 weeks after a surgically induced ISD procedure. Resting and pudendal nerve-stimulated maximal urethral pressures (MUP) were measured before, and 3 and 6 months post-skMPC treatment and urinary sphincter muscle/collagen content within the sphincter complex was measured by quantitative histology 6 months posttreatment. Efficacy of skMPCs on MUP and sphincter muscle/collagen ratios are affected by age (average 40% reduction in efficacy, p < 0.05 vs. younger NHPs), social stress (average 30% reduction in efficacy, p < 0.05 vs. socially dominant) and body weight/fasting glucose concentrations (average 35% reduction in efficacy, p < 0.05 vs. lower body weight). Multiple factors (age, stress-induced dysmenorrhea, and body weight) affect the efficacy of cell therapy to restore structure and function in the urinary sphincter complex in NHPs with ISD. Consideration of, and alternatives for, these patient cohorts should be considered." @default.
• W2571120723 created "2017-01-13" @default.
• W2571120723 creator A5014135786 @default.
• W2571120723 creator A5019564025 @default.
• W2571120723 creator A5045356209 @default.
• W2571120723 creator A5048425467 @default.
• W2571120723 creator A5048574454 @default.
• W2571120723 creator A5058238540 @default.
• W2571120723 date "2017-01-06" @default.
• W2571120723 modified "2023-10-18" @default.
• W2571120723 title "Determinates of muscle precursor cell therapy efficacy in a nonhuman primate model of intrinsic urinary sphincter deficiency" @default.
• W2571120723 cites W1511088575 @default.
• W2571120723 cites W1922672305 @default.
• W2571120723 cites W1966097784 @default.
• W2571120723 cites W1973077377 @default.
• W2571120723 cites W1980485933 @default.
• W2571120723 cites W1987184611 @default.
• W2571120723 cites W1989645465 @default.
• W2571120723 cites W1996223992 @default.
• W2571120723 cites W2039686723 @default.
• W2571120723 cites W2039700634 @default.
• W2571120723 cites W2056162760 @default.
• W2571120723 cites W2060817724 @default.
• W2571120723 cites W2072809212 @default.
• W2571120723 cites W2077609800 @default.
• W2571120723 cites W2086200581 @default.
• W2571120723 cites W2129668254 @default.
• W2571120723 cites W2137953502 @default.
• W2571120723 cites W2400828738 @default.
• W2571120723 cites W2400840102 @default.
• W2571120723 cites W2402487260 @default.
• W2571120723 cites W2494515430 @default.
• W2571120723 cites W2528825697 @default.
• W2571120723 cites W4290344418 @default.
• W2571120723 cites W82409306 @default.
• W2571120723 doi "https://doi.org/10.1186/s13287-016-0461-6" @default.
• W2571120723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5217333" @default.
• W2571120723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28057078" @default.
• W2571120723 hasPublicationYear "2017" @default.
• W2571120723 type Work @default.
• W2571120723 sameAs 2571120723 @default.
• W2571120723 citedByCount "35" @default.
• W2571120723 countsByYear W25711207232017 @default.
• W2571120723 countsByYear W25711207232018 @default.
• W2571120723 countsByYear W25711207232019 @default.
• W2571120723 countsByYear W25711207232020 @default.
• W2571120723 countsByYear W25711207232021 @default.
• W2571120723 countsByYear W25711207232022 @default.
• W2571120723 countsByYear W25711207232023 @default.
• W2571120723 crossrefType "journal-article" @default.
• W2571120723 hasAuthorship W2571120723A5014135786 @default.
• W2571120723 hasAuthorship W2571120723A5019564025 @default.
• W2571120723 hasAuthorship W2571120723A5045356209 @default.
• W2571120723 hasAuthorship W2571120723A5048425467 @default.
• W2571120723 hasAuthorship W2571120723A5048574454 @default.
• W2571120723 hasAuthorship W2571120723A5058238540 @default.
• W2571120723 hasBestOaLocation W25711207231 @default.
• W2571120723 hasConcept C118552586 @default.
• W2571120723 hasConcept C126322002 @default.
• W2571120723 hasConcept C126894567 @default.
• W2571120723 hasConcept C134018914 @default.
• W2571120723 hasConcept C141071460 @default.
• W2571120723 hasConcept C150966472 @default.
• W2571120723 hasConcept C2778531004 @default.
• W2571120723 hasConcept C2780877482 @default.
• W2571120723 hasConcept C42407357 @default.
• W2571120723 hasConcept C71924100 @default.
• W2571120723 hasConcept C77411442 @default.
• W2571120723 hasConcept C88537330 @default.
• W2571120723 hasConceptScore W2571120723C118552586 @default.
• W2571120723 hasConceptScore W2571120723C126322002 @default.
• W2571120723 hasConceptScore W2571120723C126894567 @default.
• W2571120723 hasConceptScore W2571120723C134018914 @default.
• W2571120723 hasConceptScore W2571120723C141071460 @default.
• W2571120723 hasConceptScore W2571120723C150966472 @default.
• W2571120723 hasConceptScore W2571120723C2778531004 @default.
• W2571120723 hasConceptScore W2571120723C2780877482 @default.
• W2571120723 hasConceptScore W2571120723C42407357 @default.
• W2571120723 hasConceptScore W2571120723C71924100 @default.
• W2571120723 hasConceptScore W2571120723C77411442 @default.
• W2571120723 hasConceptScore W2571120723C88537330 @default.
• W2571120723 hasFunder F4320306080 @default.
• W2571120723 hasIssue "1" @default.
• W2571120723 hasLocation W25711207231 @default.
• W2571120723 hasLocation W25711207232 @default.
• W2571120723 hasLocation W25711207233 @default.
• W2571120723 hasLocation W25711207234 @default.
• W2571120723 hasOpenAccess W2571120723 @default.
• W2571120723 hasPrimaryLocation W25711207231 @default.
• W2571120723 hasRelatedWork W170855551 @default.
• W2571120723 hasRelatedWork W1974684648 @default.
• W2571120723 hasRelatedWork W2009345711 @default.
• W2571120723 hasRelatedWork W2017130731 @default.
• W2571120723 hasRelatedWork W2025187873 @default.
• W2571120723 hasRelatedWork W2029971882 @default.
• W2571120723 hasRelatedWork W2078998944 @default.
• W2571120723 hasRelatedWork W2409907033 @default.
• W2571120723 hasRelatedWork W2418020157 @default.
• W2571120723 hasRelatedWork W2462329288 @default.
• W2571120723 hasVolume "8" @default.

• next