Matches in SemOpenAlex for { <https://semopenalex.org/work/W2571240381> ?p ?o ?g. }
- W2571240381 endingPage "337.e3" @default.
- W2571240381 startingPage "337.e1" @default.
- W2571240381 abstract "ObjectivesFaecal microbiota transplantation (FMT) is an effective treatment for recurrent Clostridium difficile infection (CDI). Although a single faecal infusion is usually sufficient to eradicate CDI, a considerable number of patients need multiple infusions to be cured. The aim of this study was to identify predictors of failure after single faecal infusion in patients with recurrent CDI.MethodsWe included patients with recurrent CDI prospectively treated with FMT by colonoscopy. By means of univariate and multivariate analysis, variables including female gender, age, number of CDI recurrences, severity of CDI, hospitalization, inadequate bowel preparation, unrelated donor, and use of frozen faeces, were assessed to predict failure after single faecal infusion.ResultsSixty-four patients (39 women; mean age 74 years) were included. Of them, 44 (69%) were cured by a single faecal infusion, whereas 20 (31%) needed repeat infusions. Overall, FMT cured 62 of 64 (97%) patients. In the subgroup of patients with severe CDI, only eight of 26 (30%) were cured with a single infusion. At multivariate analysis, severe CDI (OR 24.66; 95% CI 4.44–242.08; p 0.001) and inadequate bowel preparation (OR 11.53; 95% CI 1.71–115.51; p 0.019) were found to be independent predictors of failure after single faecal infusion.ConclusionsSevere CDI and inadequate bowel preparation appear to be independent predictors of failure after single faecal infusion in patients treated with FMT by colonoscopy for recurrent CDI. Our results may help to optimize protocols and outcomes of FMT in patients with recurrent CDI." @default.
- W2571240381 created "2017-01-13" @default.
- W2571240381 creator A5000739751 @default.
- W2571240381 creator A5001386947 @default.
- W2571240381 creator A5021409727 @default.
- W2571240381 creator A5038472987 @default.
- W2571240381 creator A5038941926 @default.
- W2571240381 creator A5053160212 @default.
- W2571240381 creator A5054710123 @default.
- W2571240381 creator A5063148714 @default.
- W2571240381 creator A5078126497 @default.
- W2571240381 creator A5085399427 @default.
- W2571240381 date "2017-05-01" @default.
- W2571240381 modified "2023-10-14" @default.
- W2571240381 title "Predictors of failure after single faecal microbiota transplantation in patients with recurrent Clostridium difficile infection: results from a 3-year, single-centre cohort study" @default.
- W2571240381 cites W1831680690 @default.
- W2571240381 cites W1916150944 @default.
- W2571240381 cites W1916481354 @default.
- W2571240381 cites W2033236889 @default.
- W2571240381 cites W2033649854 @default.
- W2571240381 cites W2077875240 @default.
- W2571240381 cites W2119114528 @default.
- W2571240381 cites W2235498129 @default.
- W2571240381 cites W2319499039 @default.
- W2571240381 cites W233588257 @default.
- W2571240381 cites W2396558681 @default.
- W2571240381 cites W2571820890 @default.
- W2571240381 doi "https://doi.org/10.1016/j.cmi.2016.12.025" @default.
- W2571240381 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28057560" @default.
- W2571240381 hasPublicationYear "2017" @default.
- W2571240381 type Work @default.
- W2571240381 sameAs 2571240381 @default.
- W2571240381 citedByCount "53" @default.
- W2571240381 countsByYear W25712403812017 @default.
- W2571240381 countsByYear W25712403812018 @default.
- W2571240381 countsByYear W25712403812019 @default.
- W2571240381 countsByYear W25712403812020 @default.
- W2571240381 countsByYear W25712403812021 @default.
- W2571240381 countsByYear W25712403812022 @default.
- W2571240381 countsByYear W25712403812023 @default.
- W2571240381 crossrefType "journal-article" @default.
- W2571240381 hasAuthorship W2571240381A5000739751 @default.
- W2571240381 hasAuthorship W2571240381A5001386947 @default.
- W2571240381 hasAuthorship W2571240381A5021409727 @default.
- W2571240381 hasAuthorship W2571240381A5038472987 @default.
- W2571240381 hasAuthorship W2571240381A5038941926 @default.
- W2571240381 hasAuthorship W2571240381A5053160212 @default.
- W2571240381 hasAuthorship W2571240381A5054710123 @default.
- W2571240381 hasAuthorship W2571240381A5063148714 @default.
- W2571240381 hasAuthorship W2571240381A5078126497 @default.
- W2571240381 hasAuthorship W2571240381A5085399427 @default.
- W2571240381 hasBestOaLocation W25712403811 @default.
- W2571240381 hasConcept C121608353 @default.
- W2571240381 hasConcept C126322002 @default.
- W2571240381 hasConcept C141071460 @default.
- W2571240381 hasConcept C144301174 @default.
- W2571240381 hasConcept C151730666 @default.
- W2571240381 hasConcept C2778435480 @default.
- W2571240381 hasConcept C2911091166 @default.
- W2571240381 hasConcept C2994496256 @default.
- W2571240381 hasConcept C38180746 @default.
- W2571240381 hasConcept C501593827 @default.
- W2571240381 hasConcept C526805850 @default.
- W2571240381 hasConcept C61716771 @default.
- W2571240381 hasConcept C71924100 @default.
- W2571240381 hasConcept C72563966 @default.
- W2571240381 hasConcept C86803240 @default.
- W2571240381 hasConcept C89423630 @default.
- W2571240381 hasConcept C90924648 @default.
- W2571240381 hasConceptScore W2571240381C121608353 @default.
- W2571240381 hasConceptScore W2571240381C126322002 @default.
- W2571240381 hasConceptScore W2571240381C141071460 @default.
- W2571240381 hasConceptScore W2571240381C144301174 @default.
- W2571240381 hasConceptScore W2571240381C151730666 @default.
- W2571240381 hasConceptScore W2571240381C2778435480 @default.
- W2571240381 hasConceptScore W2571240381C2911091166 @default.
- W2571240381 hasConceptScore W2571240381C2994496256 @default.
- W2571240381 hasConceptScore W2571240381C38180746 @default.
- W2571240381 hasConceptScore W2571240381C501593827 @default.
- W2571240381 hasConceptScore W2571240381C526805850 @default.
- W2571240381 hasConceptScore W2571240381C61716771 @default.
- W2571240381 hasConceptScore W2571240381C71924100 @default.
- W2571240381 hasConceptScore W2571240381C72563966 @default.
- W2571240381 hasConceptScore W2571240381C86803240 @default.
- W2571240381 hasConceptScore W2571240381C89423630 @default.
- W2571240381 hasConceptScore W2571240381C90924648 @default.
- W2571240381 hasIssue "5" @default.
- W2571240381 hasLocation W25712403811 @default.
- W2571240381 hasLocation W25712403812 @default.
- W2571240381 hasOpenAccess W2571240381 @default.
- W2571240381 hasPrimaryLocation W25712403811 @default.
- W2571240381 hasRelatedWork W2003938723 @default.
- W2571240381 hasRelatedWork W2015172735 @default.
- W2571240381 hasRelatedWork W2047967234 @default.
- W2571240381 hasRelatedWork W2170272972 @default.
- W2571240381 hasRelatedWork W2425239049 @default.
- W2571240381 hasRelatedWork W2439875401 @default.
- W2571240381 hasRelatedWork W2913104461 @default.